Improving survival rates of patients with idiopathic dilated cardiomyopathy in tuscany over 3 decades: Impact of evidence-based management

Gabriele Castelli, Alessandra Fornaro, Mauro Ciaccheri, Alberto Dolara, Vito Troiani, Benedetta Tomberli, Iacopo Olivotto, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Background-Contemporary therapeutic options have led to substantial improvement in survival of patients with heart failure. However, limited evidence is available specifically on idiopathic dilated cardiomyopathy. We thus examined changes in prognosis of a large idiopathic dilated cardiomyopathy cohort systematically followed during the past 30 years. Methods and Results-From 1977 to 2011, 603 consecutive patients (age, 53±12 years; 73% men; left ventricular ejection fraction, 32±10%) fulfilling World Health Organization criteria for idiopathic dilated cardiomyopathy, including negative coronary angiography, were followed up for 8.8±6.3 years. Patients were subdivided in 4 enrollment periods on the basis of heart failure treatment eras: (1) 1977-1984 (n=66); (2) 1985-1990 (n=102); (3) 1991-2000 (n=197); (4) 2001- 2011 (n=238). Rates of patients receiving angiotensin-converting enzyme inhibitors/angiotensin receptors blockers, β-blockers, and devices at final evaluation increased from 56%, 12%, 8% (period 1) to 97%, 86%, 17% (period 4), respectively (P

Original languageEnglish
Pages (from-to)913-921
Number of pages9
JournalCirculation: Heart Failure
Volume6
Issue number5
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Cardiac resynchronization therapy
  • Cardiomyopathy
  • Dilated
  • Drug therapy
  • Heart failure
  • Outcomes assessment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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