Impulse control behaviours in patients with Parkinson's disease after subthalamic deep brain stimulation: De novo cases and 3-year follow-up

P. Amami, I. Dekker, S. Piacentini, F. Ferré, L. M. Romito, A. Franzini, E. M J Foncke, A. Albanese

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Abstract

Objective To document the occurrence of impulse control behaviours (ICBs) in patients with Parkinson's disease after 3 years of continuous deep brain stimulation (DBS) of the subthalamic nucleus (STN). Methods Detailed neurological and ICB assessments were performed before STN DBS and up to 3 years after implant. Results 13 out of 56 patients (23.2%) had ICBs at baseline; they took higher doses of dopamine agonists (DAA). Three years after implant 11 had fully remitted with a 60.8% reduction of DAA medication; the remaining two, who had a similar medication reduction, had only compulsive eating, having recovered from hypersexuality. Six of the 43 patients without ICBs at baseline (14%) developed transient de novo ICBs after implant; none of them had ICBs at the 3-year observation. Conclusions ICBs were abolished in patients 3 years after STN DBS and DAA dosages were lowered. New ICBs may occur after implant and are transient in most cases. Compulsive eating may be speci fically related to STN stimulation.

Original languageEnglish
Pages (from-to)562-564
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number5
DOIs
Publication statusPublished - May 1 2015

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Behavior Control
Deep Brain Stimulation
Parkinson Disease
Subthalamic Nucleus
Dopamine Agonists
Eating
Parkinson's Disease
Impulse
Observation
Nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

Cite this

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title = "Impulse control behaviours in patients with Parkinson's disease after subthalamic deep brain stimulation: De novo cases and 3-year follow-up",
abstract = "Objective To document the occurrence of impulse control behaviours (ICBs) in patients with Parkinson's disease after 3 years of continuous deep brain stimulation (DBS) of the subthalamic nucleus (STN). Methods Detailed neurological and ICB assessments were performed before STN DBS and up to 3 years after implant. Results 13 out of 56 patients (23.2{\%}) had ICBs at baseline; they took higher doses of dopamine agonists (DAA). Three years after implant 11 had fully remitted with a 60.8{\%} reduction of DAA medication; the remaining two, who had a similar medication reduction, had only compulsive eating, having recovered from hypersexuality. Six of the 43 patients without ICBs at baseline (14{\%}) developed transient de novo ICBs after implant; none of them had ICBs at the 3-year observation. Conclusions ICBs were abolished in patients 3 years after STN DBS and DAA dosages were lowered. New ICBs may occur after implant and are transient in most cases. Compulsive eating may be speci fically related to STN stimulation.",
author = "P. Amami and I. Dekker and S. Piacentini and F. Ferr{\'e} and Romito, {L. M.} and A. Franzini and Foncke, {E. M J} and A. Albanese",
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TY - JOUR

T1 - Impulse control behaviours in patients with Parkinson's disease after subthalamic deep brain stimulation

T2 - De novo cases and 3-year follow-up

AU - Amami, P.

AU - Dekker, I.

AU - Piacentini, S.

AU - Ferré, F.

AU - Romito, L. M.

AU - Franzini, A.

AU - Foncke, E. M J

AU - Albanese, A.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objective To document the occurrence of impulse control behaviours (ICBs) in patients with Parkinson's disease after 3 years of continuous deep brain stimulation (DBS) of the subthalamic nucleus (STN). Methods Detailed neurological and ICB assessments were performed before STN DBS and up to 3 years after implant. Results 13 out of 56 patients (23.2%) had ICBs at baseline; they took higher doses of dopamine agonists (DAA). Three years after implant 11 had fully remitted with a 60.8% reduction of DAA medication; the remaining two, who had a similar medication reduction, had only compulsive eating, having recovered from hypersexuality. Six of the 43 patients without ICBs at baseline (14%) developed transient de novo ICBs after implant; none of them had ICBs at the 3-year observation. Conclusions ICBs were abolished in patients 3 years after STN DBS and DAA dosages were lowered. New ICBs may occur after implant and are transient in most cases. Compulsive eating may be speci fically related to STN stimulation.

AB - Objective To document the occurrence of impulse control behaviours (ICBs) in patients with Parkinson's disease after 3 years of continuous deep brain stimulation (DBS) of the subthalamic nucleus (STN). Methods Detailed neurological and ICB assessments were performed before STN DBS and up to 3 years after implant. Results 13 out of 56 patients (23.2%) had ICBs at baseline; they took higher doses of dopamine agonists (DAA). Three years after implant 11 had fully remitted with a 60.8% reduction of DAA medication; the remaining two, who had a similar medication reduction, had only compulsive eating, having recovered from hypersexuality. Six of the 43 patients without ICBs at baseline (14%) developed transient de novo ICBs after implant; none of them had ICBs at the 3-year observation. Conclusions ICBs were abolished in patients 3 years after STN DBS and DAA dosages were lowered. New ICBs may occur after implant and are transient in most cases. Compulsive eating may be speci fically related to STN stimulation.

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