Impulsivity and compulsivity in drug-naïve patients with Parkinson's disease

Angelo Antonini, Chiara Siri, Gabriella Santangelo, Roberto Cilia, Michele Poletti, Margherita Canesi, Alessandra Caporali, Francesca Mancini, Gianni Pezzoli, Roberto Ceravolo, Ubaldo Bonuccelli, Paolo Barone

Research output: Contribution to journalArticle

Abstract

Background: Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort. Methods: 103 consecutive newly diagnosed drug-naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS-11) and Maudsley Obsessional-Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive-compulsive symptoms, respectively. Depression (GDS-15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls. Results: 17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM-IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS-11 attentive-impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; P = 0.007) and in MOCQ/R-Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; P = 0.007) in PD with ICD. We also observed a positive correlation between GDS-15 and BIS-11. Conclusions: Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended.

Original languageEnglish
Pages (from-to)464-468
Number of pages5
JournalMovement Disorders
Volume26
Issue number3
DOIs
Publication statusPublished - Feb 15 2011

Keywords

  • Compulsivity
  • Drug naïve
  • Impulse control disorders
  • Impulsivity
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Antonini, A., Siri, C., Santangelo, G., Cilia, R., Poletti, M., Canesi, M., Caporali, A., Mancini, F., Pezzoli, G., Ceravolo, R., Bonuccelli, U., & Barone, P. (2011). Impulsivity and compulsivity in drug-naïve patients with Parkinson's disease. Movement Disorders, 26(3), 464-468. https://doi.org/10.1002/mds.23501