In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics

Gian Matteo Rigolin, Elena Saccenti, Emanuele Guardalben, Maurizio Cavallari, Luca Formigaro, Barbara Zagatti, Andrea Visentin, Francesca R. Mauro, Enrico Lista, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Antonio Urso, Maria Antonella Bardi, Laura Bonaldi, Eleonora Volta, Elisa Tammiso, Caterina Ilari, Luciana Cafforio, Aurora MelandriFrancesco Cavazzini, Massimo Negrini, Gianpietro Semenzato, Livio Trentin, Robin Foà, Antonio Cuneo

Research output: Contribution to journalArticle

Abstract

Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalBritish Journal of Haematology
Volume181
Issue number2
DOIs
Publication statusPublished - Apr 1 2018

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Keywords

  • chronic lymphocytic leukaemia
  • complex karyotype
  • gene expression profile
  • overall survival
  • time to first treatment

ASJC Scopus subject areas

  • Hematology

Cite this

Rigolin, G. M., Saccenti, E., Guardalben, E., Cavallari, M., Formigaro, L., Zagatti, B., Visentin, A., Mauro, F. R., Lista, E., Bassi, C., Lupini, L., Quaglia, F. M., Urso, A., Bardi, M. A., Bonaldi, L., Volta, E., Tammiso, E., Ilari, C., Cafforio, L., ... Cuneo, A. (2018). In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics. British Journal of Haematology, 181(2), 229-233. https://doi.org/10.1111/bjh.15174