Abstract
Background: Histologic detection of Helicobacter pylori shows high diagnostic accuracy in chronic nonatrophic gastritis. However, when atrophy occurs, the sensitivity of bacterial detection varies. This study assessed the routine histologic sensitivity for current H. pylori infection in patients with atrophic gastritis, with and without intestinal metaplasia. Study: Five hundred and ten consecutive patients with diffuse chronic atrophic gastritis, with (174 cases) and without (336 cases) intestinal metaplasia, were investigated following the Sydney System recommendations. In cases with negative tissue staining for Helicobacter-like organisms, serum immunoglobulin G (IgG) antibodies to H. pylori were assayed. Results: The overall rate of positive staining for Helicobacter-like organisms was 51.8% (264 of 510 cases), 62.8% and 30.4% in cases without and with intestinal metaplasia, respectively. Serum IgG antibody determination was consistent with current infection in 180 (73.2%) of the 246 cases with negative histology. H. pylori detection rate was significantly lower (p
| Original language | English |
|---|---|
| Pages (from-to) | 234-239 |
| Number of pages | 6 |
| Journal | Journal of Clinical Gastroenterology |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2002 |
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Keywords
- Atrophic gastritis
- Helicobacter pylori
- Histology
- Intestinal metaplasia
ASJC Scopus subject areas
- Gastroenterology
Cite this
In diffuse atrophic gastritis, routine histology underestimates Helicobacter pylori infection. / Testoni, Pier Alberto; Bonassi, Umberto; Bagnolo, Francesco; Colombo, Elena; Scelsi, Roberto.
In: Journal of Clinical Gastroenterology, Vol. 35, No. 3, 09.2002, p. 234-239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In diffuse atrophic gastritis, routine histology underestimates Helicobacter pylori infection
AU - Testoni, Pier Alberto
AU - Bonassi, Umberto
AU - Bagnolo, Francesco
AU - Colombo, Elena
AU - Scelsi, Roberto
PY - 2002/9
Y1 - 2002/9
N2 - Background: Histologic detection of Helicobacter pylori shows high diagnostic accuracy in chronic nonatrophic gastritis. However, when atrophy occurs, the sensitivity of bacterial detection varies. This study assessed the routine histologic sensitivity for current H. pylori infection in patients with atrophic gastritis, with and without intestinal metaplasia. Study: Five hundred and ten consecutive patients with diffuse chronic atrophic gastritis, with (174 cases) and without (336 cases) intestinal metaplasia, were investigated following the Sydney System recommendations. In cases with negative tissue staining for Helicobacter-like organisms, serum immunoglobulin G (IgG) antibodies to H. pylori were assayed. Results: The overall rate of positive staining for Helicobacter-like organisms was 51.8% (264 of 510 cases), 62.8% and 30.4% in cases without and with intestinal metaplasia, respectively. Serum IgG antibody determination was consistent with current infection in 180 (73.2%) of the 246 cases with negative histology. H. pylori detection rate was significantly lower (p
AB - Background: Histologic detection of Helicobacter pylori shows high diagnostic accuracy in chronic nonatrophic gastritis. However, when atrophy occurs, the sensitivity of bacterial detection varies. This study assessed the routine histologic sensitivity for current H. pylori infection in patients with atrophic gastritis, with and without intestinal metaplasia. Study: Five hundred and ten consecutive patients with diffuse chronic atrophic gastritis, with (174 cases) and without (336 cases) intestinal metaplasia, were investigated following the Sydney System recommendations. In cases with negative tissue staining for Helicobacter-like organisms, serum immunoglobulin G (IgG) antibodies to H. pylori were assayed. Results: The overall rate of positive staining for Helicobacter-like organisms was 51.8% (264 of 510 cases), 62.8% and 30.4% in cases without and with intestinal metaplasia, respectively. Serum IgG antibody determination was consistent with current infection in 180 (73.2%) of the 246 cases with negative histology. H. pylori detection rate was significantly lower (p
KW - Atrophic gastritis
KW - Helicobacter pylori
KW - Histology
KW - Intestinal metaplasia
UR - http://www.scopus.com/inward/record.url?scp=0036720624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036720624&partnerID=8YFLogxK
U2 - 10.1097/00004836-200209000-00007
DO - 10.1097/00004836-200209000-00007
M3 - Article
C2 - 12192199
AN - SCOPUS:0036720624
VL - 35
SP - 234
EP - 239
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
SN - 0192-0790
IS - 3
ER -