In-hospital costs in patients with seizures and epilepsy after stroke

Alla Guekht, Maria Mizinova, Andrey Ershov, Denis Guz, Igor Kaimovsky, Paolo Messina, Ettore Beghi

Research output: Contribution to journalArticlepeer-review


Summary Objectives To verify the net effect of seizures after stroke on the use of in-hospital health care resources. Methods Consecutive patients with first-ever stroke were admitted to the stroke unit of a Moscow hospital and followed prospectively until death or discharge. Each patient experiencing seizures was matched for age, sex, stroke type, National Institutes of Health Stroke Scale score at admission, and stroke risk factors to 2+ patients with no seizures, as controls. Resources consumed included length of hospital stay, admission to the intensive care unit (ICU), diagnostic tests, medical consultations and treatments. Cost estimates were based on the Russian National Health Service perspective. Results The sample comprised 30 patients with in-hospital seizures and 70 matched controls. Patients dying in hospital were 15 of 30 (50%) versus 4 of 70 (5.7%) (p <0.001). The overall cost of hospital stay was only slightly (nonsignificantly) higher in patients with seizures, but the cost was significantly higher in patients who died than in patients who were discharged alive. Compared to the controls, patients with seizures spent more intensive care unit (ICU) days and required more computed tomography (CT) scans, x-rays, endoscopies, and specialist consultations, causing higher in-hospital costs. Significance In patients with first-ever stroke, seizures per se do not increase the overall in-hospital costs. However, the higher than expected mortality in patients with seizures is associated with additional hospital costs.

Original languageEnglish
Pages (from-to)1309-1313
Number of pages5
Issue number8
Publication statusPublished - Aug 1 2015


  • Direct costs
  • Epilepsy
  • Russia
  • Seizures
  • Stroke
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)


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