Abstract
Objective The aim of the study was to explore the association of dementia with in-hospital death in acutely ill medical patients. Methods Thirty-four internal medicine and 4 geriatric wards in Italy participated in the Registro Politerapie SIMI-REPOSI-study during 2008. One thousand three hundred and thirty two in-patients aged 65 years or older were enrolled. Logistic regression models were used to evaluate the association of dementia with in-hospital death. Socio-demographic characteristics, morbidity (single diseases and the Charlson Index), number of drugs, and adverse clinical events during hospitalization were considered as potential confounders. Results One hundred and seventeen participants were diagnosed as being affected by dementia. Patients with dementia were more likely to be women, older, to have cerebrovascular diseases, pneumonia, and a higher number of adverse clinical events during hospitalization. The percentage of patients affected by dementia who died during hospitalization was higher than that of patients without dementia (9.4 versus 4.9%). After multiadjustment, the diagnosis of dementia was associated with in-hospital death (OR = 2.1; 95% CI = 1.0-4.5). Having dementia and at least one adverse clinical event during hospitalization showed an additive effect on in-hospital mortality (OR = 20.7; 95% CI = 6.9-61.9). Conclusions Acutely ill elderly patients affected by dementia are more likely to die shortly after hospital admission. Having dementia and adverse clinical events during hospital stay increases the risk of death.
| Original language | English |
|---|---|
| Pages (from-to) | 930-936 |
| Number of pages | 7 |
| Journal | International Journal of Geriatric Psychiatry |
| Volume | 26 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2011 |
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Keywords
- acute illnesses
- dementia
- hospitalization
- mortality
- older patients
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
In-hospital death according to dementia diagnosis in acutely ill elderly patients : The REPOSI study. / Marengoni, A.; Corrao, S.; Nobili, A.; Tettamanti, M.; Pasina, L.; Salerno, F.; Iorio, A.; Marcucci, M.; Bonometti, F.; Mannucci, P. M.
In: International Journal of Geriatric Psychiatry, Vol. 26, No. 9, 09.2011, p. 930-936.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In-hospital death according to dementia diagnosis in acutely ill elderly patients
T2 - The REPOSI study
AU - Marengoni, A.
AU - Corrao, S.
AU - Nobili, A.
AU - Tettamanti, M.
AU - Pasina, L.
AU - Salerno, F.
AU - Iorio, A.
AU - Marcucci, M.
AU - Bonometti, F.
AU - Mannucci, P. M.
PY - 2011/9
Y1 - 2011/9
N2 - Objective The aim of the study was to explore the association of dementia with in-hospital death in acutely ill medical patients. Methods Thirty-four internal medicine and 4 geriatric wards in Italy participated in the Registro Politerapie SIMI-REPOSI-study during 2008. One thousand three hundred and thirty two in-patients aged 65 years or older were enrolled. Logistic regression models were used to evaluate the association of dementia with in-hospital death. Socio-demographic characteristics, morbidity (single diseases and the Charlson Index), number of drugs, and adverse clinical events during hospitalization were considered as potential confounders. Results One hundred and seventeen participants were diagnosed as being affected by dementia. Patients with dementia were more likely to be women, older, to have cerebrovascular diseases, pneumonia, and a higher number of adverse clinical events during hospitalization. The percentage of patients affected by dementia who died during hospitalization was higher than that of patients without dementia (9.4 versus 4.9%). After multiadjustment, the diagnosis of dementia was associated with in-hospital death (OR = 2.1; 95% CI = 1.0-4.5). Having dementia and at least one adverse clinical event during hospitalization showed an additive effect on in-hospital mortality (OR = 20.7; 95% CI = 6.9-61.9). Conclusions Acutely ill elderly patients affected by dementia are more likely to die shortly after hospital admission. Having dementia and adverse clinical events during hospital stay increases the risk of death.
AB - Objective The aim of the study was to explore the association of dementia with in-hospital death in acutely ill medical patients. Methods Thirty-four internal medicine and 4 geriatric wards in Italy participated in the Registro Politerapie SIMI-REPOSI-study during 2008. One thousand three hundred and thirty two in-patients aged 65 years or older were enrolled. Logistic regression models were used to evaluate the association of dementia with in-hospital death. Socio-demographic characteristics, morbidity (single diseases and the Charlson Index), number of drugs, and adverse clinical events during hospitalization were considered as potential confounders. Results One hundred and seventeen participants were diagnosed as being affected by dementia. Patients with dementia were more likely to be women, older, to have cerebrovascular diseases, pneumonia, and a higher number of adverse clinical events during hospitalization. The percentage of patients affected by dementia who died during hospitalization was higher than that of patients without dementia (9.4 versus 4.9%). After multiadjustment, the diagnosis of dementia was associated with in-hospital death (OR = 2.1; 95% CI = 1.0-4.5). Having dementia and at least one adverse clinical event during hospitalization showed an additive effect on in-hospital mortality (OR = 20.7; 95% CI = 6.9-61.9). Conclusions Acutely ill elderly patients affected by dementia are more likely to die shortly after hospital admission. Having dementia and adverse clinical events during hospital stay increases the risk of death.
KW - acute illnesses
KW - dementia
KW - hospitalization
KW - mortality
KW - older patients
UR - http://www.scopus.com/inward/record.url?scp=80051893552&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051893552&partnerID=8YFLogxK
U2 - 10.1002/gps.2627
DO - 10.1002/gps.2627
M3 - Article
C2 - 21845595
AN - SCOPUS:80051893552
VL - 26
SP - 930
EP - 936
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 9
ER -