In line with our ancestors: Oct-4 and the mammalian germ

Maurizio Pesce, Michael K. Gross, Hans R. Schöler

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing al other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation.

Original languageEnglish
Pages (from-to)722-732
Number of pages11
JournalBioEssays
Volume20
Issue number9
Publication statusPublished - Sep 1998

Fingerprint

Germ Cells
Octamer Transcription Factor-3
germ cells
ancestry
Cells
Carisoprodol
Blastocyst Inner Cell Mass
Tissue
Morula
Germ Layers
Blastomeres
Zygote
cells
blastomeres
morula
Cell Differentiation
Stem Cells
blastocyst
cell differentiation
transcription factors

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Pesce, M., Gross, M. K., & Schöler, H. R. (1998). In line with our ancestors: Oct-4 and the mammalian germ. BioEssays, 20(9), 722-732.

In line with our ancestors : Oct-4 and the mammalian germ. / Pesce, Maurizio; Gross, Michael K.; Schöler, Hans R.

In: BioEssays, Vol. 20, No. 9, 09.1998, p. 722-732.

Research output: Contribution to journalArticle

Pesce, M, Gross, MK & Schöler, HR 1998, 'In line with our ancestors: Oct-4 and the mammalian germ', BioEssays, vol. 20, no. 9, pp. 722-732.
Pesce M, Gross MK, Schöler HR. In line with our ancestors: Oct-4 and the mammalian germ. BioEssays. 1998 Sep;20(9):722-732.
Pesce, Maurizio ; Gross, Michael K. ; Schöler, Hans R. / In line with our ancestors : Oct-4 and the mammalian germ. In: BioEssays. 1998 ; Vol. 20, No. 9. pp. 722-732.
@article{fe9aa1e82dcb428f8da3fae8bd6e6215,
title = "In line with our ancestors: Oct-4 and the mammalian germ",
abstract = "The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing al other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation.",
author = "Maurizio Pesce and Gross, {Michael K.} and Sch{\"o}ler, {Hans R.}",
year = "1998",
month = "9",
language = "English",
volume = "20",
pages = "722--732",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - In line with our ancestors

T2 - Oct-4 and the mammalian germ

AU - Pesce, Maurizio

AU - Gross, Michael K.

AU - Schöler, Hans R.

PY - 1998/9

Y1 - 1998/9

N2 - The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing al other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation.

AB - The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing al other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0032170283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032170283&partnerID=8YFLogxK

M3 - Article

C2 - 9819561

AN - SCOPUS:0032170283

VL - 20

SP - 722

EP - 732

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 9

ER -