In nimodipine useful in migraine prophylaxis? Further considerations

M. Leone, F. Frediani, G. Patruno, S. Valentini, G. Bussone

Research output: Contribution to journalArticlepeer-review


Nimodipine is one of the most discussed calcium antagonists used in cerebrovascular diseases and, recently, in migraine prophylaxis. Its specificity in preventing cerebral arterial constriction has been invoked to explain nimodipine's efficacy in migraine. The discovery of neuronal receptors specific for dihydropyridines, however, favours a mechanism of action for nimodipine that is not exclusively vascular. This is in accordance with a view of migraine pathogenesis which implicates a primary neuronal event as the basis of the vascular changes observed in migraine patients.

Original languageEnglish
Pages (from-to)363-365
Number of pages3
Issue number6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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