In PC12 cells neurotoxicity induced by methamphetamine is related to proteasome inhibition

Gloria Lazzeri, Paola Lenzi, Marco Gesi, Michela Ferrucci, Federica Fulceri, Stefano Ruggieri, Valeria Bruno, Francesco Fornai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Neurodegenerative disorders are featured by a variety of pathological hallmarks, and very often they are characterized by neuronal inclusions in specific brain nuclei. Occurrence of neuronal inclusions has been often related to the onset of cell death. Recent studies demonstrated that amphetamine derivatives produce intracellular inclusions, which are reminiscent of those occurring in degenerative disorders. In the present article, we analyzed the correlation between neuronal inclusions and cell death using methamphetamine (METH) in PC12 cell cultures. We found that the dose necessary to induce cell death is higher compared with that required to induce inclusions formation. Our results demonstrate a dissociation between formation of inclusion bodies and cell death suggesting that neuronal inclusions do not necessarily lead to cell death. The conclusions of the present article suggest that the onset of inclusion bodies represents a slight consequence of toxicity, which requires a prolonged cell viability to take place.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages4
Publication statusPublished - Aug 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Cell death
  • Methamphetamine
  • Neuronal inclusions
  • Proteasome inhibition

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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