In postmenopausal female subjects with type 2 diabetes mellitus, vertebral fractures are independently associated with cortisol secretion and sensitivity

Volha V. Zhukouskaya, Cristina Eller-Vainicher, Agostino Gaudio, Elisa Cairoli, Fabio Massimo Ulivieri, Serena Palmieri, Valentina Morelli, Emanuela Orsi, Benedetta Masserini, Anna Maria Barbieri, Elisa Polledri, Silvia Fustinoni, Anna Spada, Carmelo Erio Fiore, Iacopo Chiodini

Research output: Contribution to journalArticle

Abstract

Context: In type 2 diabetes (T2D), the vertebral fracture (VFx) prevalence and cortisol secretion are increased. Objective: The objective of this study was to evaluate the role of glucocorticoid secretion and sensitivity in T2D-related osteoporosis. Design and Setting: This was a case-control study in an outpatient setting. Patients: The patients were ninety-nine well-compensated T2D postmenopausal women (age, 65.7 ± 7.3 y) and 107 controls (age, 64.5 ± 8.2 y). Main Outcome Measures: We assessed osteocalcin, C-terminal telopeptide of type I collagen, ACTH, cortisol after the dexamethasone suppression test (F-1mgDST), BclI and N363S single-nucleotide polymorphisms (SNPs) of glucocorticoid receptor, lumbar spine and femoral neck bone mineral density by dual x-ray absorptiometry, and VFx by radiography. Results: Comparedwith controls, T2Dsubjectshadincreased VFx prevalence (20 vs 34.3%, respectively; P =.031), bone mineral density (Z-scores, lumbar spine, 0.16 ± 1.28 vs 0.78 ± 1.43, P =.001; femoral neck, -0.03 ± 0.87 vs 0.32 ± 0.98, P =.008, respectively), and F-1mgDST (1.06 ± 0.42 vs 1.21 ± 0.44 ±g/dL, 29.2 ± 1.2 vs 33.3 ± 1.2 nmol/L, respectively; P =.01), and decreased osteocalcin (10.6 ± 6.4 vs 4.9±3.2 μg/mL, 10.6±6.4 vs 4.9±3.2±g/L, respectively; P

Original languageEnglish
Pages (from-to)1417-1425
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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