In silico dissection of miRNA targetome polymorphisms and their role in regulating miRNA-mediated gene expression in esophageal cancer

Ziba Nariman-Saleh-Fam, Milad Bastami, Mohammad Hossein Somi, Naser Samadi, Mohammad Reza Abbaszadegan, Farkhondeh Behjati, Hamid Ghaedi, Javad Tavakkoly-Bazzaz, Andrea Masotti

Research output: Contribution to journalArticlepeer-review

Abstract

Esophageal cancer is the eighth most common cancer worldwide. Also middle-aged obese adults with higher body mass index during childhood have a greater risk to develop esophageal cancer. The contribution of microRNAs to esophageal cancer has been extensively studied and it became clear that these noncoding RNAs may play crucial roles in pathogenesis, diagnosis and prognosis of the disease. Increasing evidences have suggested that polymorphisms perturbing microRNA targetome (i.e., the compendium of all microRNA target sites) are associated with cancers including esophageal cancer. However, the extent to which such variants contribute to esophageal cancer is still unclear. In this study, we applied an in silico approach to systematically identify polymorphisms perturbing microRNA targetome in esophageal cancer and performed various analyses to predict the functional consequences of the occurrence of these variants. The computational results were integrated to provide a prioritized list of the most potentially disrupting esophageal cancer-implicated microRNA targetome polymorphisms along with the in silico insight into the mechanisms with which such variations may modulate microRNA-mediated regulation. The results of this study will be valuable for future functional experiments aimed at dissecting the roles of microRNA targetome polymorphisms in the onset and progression of esophageal cancer.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalCell Biochemistry and Biophysics
DOIs
Publication statusAccepted/In press - Aug 12 2016

Keywords

  • Bioinformatics
  • Esophageal Cancer
  • MicroRNAs
  • miRNA target sites
  • Polymorphism

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'In silico dissection of miRNA targetome polymorphisms and their role in regulating miRNA-mediated gene expression in esophageal cancer'. Together they form a unique fingerprint.

Cite this