In silico prediction of the cell proliferation in porous scaffold using model of effective pore

A. Makhaniok, Y. Haranava, V. Goranov, S. Panseri, S. Semerikhina, A. Russo, M. Marcacci, V. Dediu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The mathematical prediction of cell proliferation in porous scaffold still remains a challenge. The analysis of existing models and experimental data confirms a need for a new solution, which takes into account cells" development on the scaffold pore walls as well as some additional parameters such as the pore size, cell density in cellular layers, the thickness of the growing cell layer and others. The simulations, presented below, are based on three main approaches. The first approach takes into account multilayer cell growth on the pore walls of the scaffold. The second approach is a simulation of cell proliferation in a discrete process as a continuous one. The third one is the representation of scaffold structure as a system of cylindrical channels. Oxygen (nutrient) mass transfer is realized inside these channels. The model, described below, proposes the new solution to time dependent description of cell proliferation in porous scaffold and optimized trophical conditions for tissue development.

Original languageEnglish
Pages (from-to)227-237
Number of pages11
JournalBioSystems
Volume114
Issue number3
DOIs
Publication statusPublished - 2013

Fingerprint

Cell Proliferation
Scaffold
Cell proliferation
Scaffolds (biology)
Computer Simulation
Scaffolds
Prediction
Cell growth
Cell
Density (specific gravity)
Nutrients
Pore size
Multilayers
Theoretical Models
Mass transfer
Cell Count
Cells
Model
Cell Size
Tissue

Keywords

  • Cell density
  • Cell proliferation
  • Diffusion
  • Mathematical modeling
  • Oxygen uptake rate
  • Porous scaffold

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics
  • Modelling and Simulation
  • Statistics and Probability
  • Medicine(all)

Cite this

Makhaniok, A., Haranava, Y., Goranov, V., Panseri, S., Semerikhina, S., Russo, A., ... Dediu, V. (2013). In silico prediction of the cell proliferation in porous scaffold using model of effective pore. BioSystems, 114(3), 227-237. https://doi.org/10.1016/j.biosystems.2013.10.001

In silico prediction of the cell proliferation in porous scaffold using model of effective pore. / Makhaniok, A.; Haranava, Y.; Goranov, V.; Panseri, S.; Semerikhina, S.; Russo, A.; Marcacci, M.; Dediu, V.

In: BioSystems, Vol. 114, No. 3, 2013, p. 227-237.

Research output: Contribution to journalArticle

Makhaniok, A, Haranava, Y, Goranov, V, Panseri, S, Semerikhina, S, Russo, A, Marcacci, M & Dediu, V 2013, 'In silico prediction of the cell proliferation in porous scaffold using model of effective pore', BioSystems, vol. 114, no. 3, pp. 227-237. https://doi.org/10.1016/j.biosystems.2013.10.001
Makhaniok, A. ; Haranava, Y. ; Goranov, V. ; Panseri, S. ; Semerikhina, S. ; Russo, A. ; Marcacci, M. ; Dediu, V. / In silico prediction of the cell proliferation in porous scaffold using model of effective pore. In: BioSystems. 2013 ; Vol. 114, No. 3. pp. 227-237.
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