In situ hybridization analysis of preprotachykinin-A mRNA levels in young and old rats

P. Pompei, R. Severini, D. Pediconi, D. Martarelli, M. Massi, P. Fattoretti, C. Bertoni-Freddari

Research output: Contribution to journalArticlepeer-review

Abstract

Preprotachykinin-A (PPT-A) mRNA levels in discrete rat brain regions were examined. Analysis of silver grains revealed a 19.2% and 31.5% statistically significant decrease in PPT-A mRNA in the dorsal and ventral caudate putamen (d-CPu and v-CPu), respectively, a 30% lower expression of PPT-A mRNA in the bed nucleus of the stria terminalis (BNST), a 33.7% decrease in PPT-A mRNA in the habenula (Hb), and a 30% decrease of PPT-A mRNA levels in the posterodorsal part of the medial amygdala (MePD). Results show that aging of the CNS is associated with widespread changes in tachykinin gene expression, suggesting that alterations in the tachykinergic system may have implications in the physiopathology of the elderly.

Original languageEnglish
Pages (from-to)1325-1326
Number of pages2
JournalJournal of Histochemistry and Cytochemistry
Volume49
Issue number10
Publication statusPublished - 2001

Keywords

  • Aging PPT-A in situ hybridization substance P

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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