In situ hybridization and immunogold localization of vascular endothelial growth factor receptor-2 on the pericytes of the chick chorioallantoic membrane

Domenico Ribatti, Amauri Cruz, Beatrice Nico, Judith Favier, Angelo Vacca, Patrizia Corsi, Luisa Roncali, Franco Dammacco

Research output: Contribution to journalArticle

Abstract

This paper describes the expression of VEGF and of VEGFR-2 in the vasculature of the chorioallantoic membrane (CAM) as revealed by in situ hybridization and immunoelectron microscopy. Results showed that VEGFR-2 is expressed in both the endothelial cells and the pericytes, while VEGF in the chorionic epithelial cells. VEGF may therefore be released to promote both angiogenesis, by initiating an angiogenic response by endothelial cells expressing VEGFR-2, and the recruitment of pericytes along the capillary wall, playing also a crucial role in maturation and stabilization of the CAM blood vessels.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalCytokine
Volume17
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Angiogenesis
  • Chorioallantoic membrane
  • Pericyte
  • VEGF
  • VEGFR-2

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

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