In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1

T. Gress, A. Baldini, M. Rocchi, H. Furneaux, J. B. Posner, M. Siniscalco

Research output: Contribution to journalArticle

Abstract

A cDNA clone encoding the major antigen (CDR62) associated with the antibody-induced paraneoplastic cerebellar degeneration has been used to identify the chromosomal location of the corresponding structural gene(s) by screening for its retention in a panel of rodent-human somatic cell hybrids. Having established the synteny of the gene with the autosome 16, we proceeded to its precise subregional mapping by in situ fluorescence hybridization with a recombinant lambda phage containing the genomic region homologous to the cDNA gene. The latter studies pin-pointed the chromosomal localization of the structural CDR62 gene within the interval 16p12-16p13.1.

Original languageEnglish
Pages (from-to)1340-1342
Number of pages3
JournalGenomics
Volume13
Issue number4
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Genetics

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