Abstract
A cDNA clone encoding the major antigen (CDR62) associated with the antibody-induced paraneoplastic cerebellar degeneration has been used to identify the chromosomal location of the corresponding structural gene(s) by screening for its retention in a panel of rodent-human somatic cell hybrids. Having established the synteny of the gene with the autosome 16, we proceeded to its precise subregional mapping by in situ fluorescence hybridization with a recombinant lambda phage containing the genomic region homologous to the cDNA gene. The latter studies pin-pointed the chromosomal localization of the structural CDR62 gene within the interval 16p12-16p13.1.
Original language | English |
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Pages (from-to) | 1340-1342 |
Number of pages | 3 |
Journal | Genomics |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1992 |
ASJC Scopus subject areas
- Genetics