In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1

T. Gress, A. Baldini, M. Rocchi, H. Furneaux, J. B. Posner, M. Siniscalco

Research output: Contribution to journalArticle

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Abstract

A cDNA clone encoding the major antigen (CDR62) associated with the antibody-induced paraneoplastic cerebellar degeneration has been used to identify the chromosomal location of the corresponding structural gene(s) by screening for its retention in a panel of rodent-human somatic cell hybrids. Having established the synteny of the gene with the autosome 16, we proceeded to its precise subregional mapping by in situ fluorescence hybridization with a recombinant lambda phage containing the genomic region homologous to the cDNA gene. The latter studies pin-pointed the chromosomal localization of the structural CDR62 gene within the interval 16p12-16p13.1.

Original languageEnglish
Pages (from-to)1340-1342
Number of pages3
JournalGenomics
Volume13
Issue number4
DOIs
Publication statusPublished - 1992

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Leucine Zippers
Chromosome Mapping
DNA-Binding Proteins
Genes
Paraneoplastic Cerebellar Degeneration
Complementary DNA
Synteny
Bacteriophage lambda
Hybrid Cells
Fluorescence In Situ Hybridization
Rodentia
Clone Cells
Antigens
Antibodies

ASJC Scopus subject areas

  • Genetics

Cite this

Gress, T., Baldini, A., Rocchi, M., Furneaux, H., Posner, J. B., & Siniscalco, M. (1992). In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1. Genomics, 13(4), 1340-1342. https://doi.org/10.1016/0888-7543(92)90063-X

In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1. / Gress, T.; Baldini, A.; Rocchi, M.; Furneaux, H.; Posner, J. B.; Siniscalco, M.

In: Genomics, Vol. 13, No. 4, 1992, p. 1340-1342.

Research output: Contribution to journalArticle

Gress, T, Baldini, A, Rocchi, M, Furneaux, H, Posner, JB & Siniscalco, M 1992, 'In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1', Genomics, vol. 13, no. 4, pp. 1340-1342. https://doi.org/10.1016/0888-7543(92)90063-X
Gress, T. ; Baldini, A. ; Rocchi, M. ; Furneaux, H. ; Posner, J. B. ; Siniscalco, M. / In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1. In: Genomics. 1992 ; Vol. 13, No. 4. pp. 1340-1342.
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