In utero exposure to compounds with dioxin-like activity and birth outcomes

Marina Vafeiadi; Silvia Agramunt; Marie Pedersen; Harrie Besselink; Leda Chatzi; Eleni Fthenou; Sarah Fleming; Laura J. Hardie; John Wright; Lisbeth E. Knudsen; Jeanette K S Nielsen; Jordi Sunyer; Ramon Carreras; Gunnar Brunborg; Kristine B. Gutzkow; Unni C. Nygaard; Martinus Løvik; Soterios A. Kyrtopoulos; Dan Segerbäck; Domenico F. Merlo; Jos C. Kleinjans; Martine Vrijheid; Manolis Kogevinas

doi:10.1097/EDE.0000000000000046

In utero exposure to compounds with dioxin-like activity and birth outcomes

Marina Vafeiadi, Silvia Agramunt, Marie Pedersen, Harrie Besselink, Leda Chatzi, Eleni Fthenou, Sarah Fleming, Laura J. Hardie, John Wright, Lisbeth E. Knudsen, Jeanette K S Nielsen, Jordi Sunyer, Ramon Carreras, Gunnar Brunborg, Kristine B. Gutzkow, Unni C. Nygaard, Martinus Løvik, Soterios A. Kyrtopoulos, Dan Segerbäck, Domenico F. MerloJos C. Kleinjans, Martine Vrijheid, Manolis Kogevinas

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND:: Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study. METHODS:: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference. RESULTS:: Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes. CONCLUSIONS:: Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.

Original language	English
Pages (from-to)	215-224
Number of pages	10
Journal	Epidemiology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1097/EDE.0000000000000046
Publication status	Published - Mar 2014

ASJC Scopus subject areas

Epidemiology

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Vafeiadi, M., Agramunt, S., Pedersen, M., Besselink, H., Chatzi, L., Fthenou, E., Fleming, S., Hardie, L. J., Wright, J., Knudsen, L. E., Nielsen, J. K. S., Sunyer, J., Carreras, R., Brunborg, G., Gutzkow, K. B., Nygaard, U. C., Løvik, M., Kyrtopoulos, S. A., Segerbäck, D., ... Kogevinas, M. (2014). In utero exposure to compounds with dioxin-like activity and birth outcomes. Epidemiology, 25(2), 215-224. https://doi.org/10.1097/EDE.0000000000000046

In utero exposure to compounds with dioxin-like activity and birth outcomes. / Vafeiadi, Marina; Agramunt, Silvia; Pedersen, Marie; Besselink, Harrie; Chatzi, Leda; Fthenou, Eleni; Fleming, Sarah; Hardie, Laura J.; Wright, John; Knudsen, Lisbeth E.; Nielsen, Jeanette K S; Sunyer, Jordi; Carreras, Ramon; Brunborg, Gunnar; Gutzkow, Kristine B.; Nygaard, Unni C.; Løvik, Martinus; Kyrtopoulos, Soterios A.; Segerbäck, Dan; Merlo, Domenico F.; Kleinjans, Jos C.; Vrijheid, Martine; Kogevinas, Manolis.

In: Epidemiology, Vol. 25, No. 2, 03.2014, p. 215-224.

Research output: Contribution to journal › Article › peer-review

Vafeiadi, M, Agramunt, S, Pedersen, M, Besselink, H, Chatzi, L, Fthenou, E, Fleming, S, Hardie, LJ, Wright, J, Knudsen, LE, Nielsen, JKS, Sunyer, J, Carreras, R, Brunborg, G, Gutzkow, KB, Nygaard, UC, Løvik, M, Kyrtopoulos, SA, Segerbäck, D, Merlo, DF, Kleinjans, JC, Vrijheid, M & Kogevinas, M 2014, 'In utero exposure to compounds with dioxin-like activity and birth outcomes', Epidemiology, vol. 25, no. 2, pp. 215-224. https://doi.org/10.1097/EDE.0000000000000046

Vafeiadi, Marina ; Agramunt, Silvia ; Pedersen, Marie ; Besselink, Harrie ; Chatzi, Leda ; Fthenou, Eleni ; Fleming, Sarah ; Hardie, Laura J. ; Wright, John ; Knudsen, Lisbeth E. ; Nielsen, Jeanette K S ; Sunyer, Jordi ; Carreras, Ramon ; Brunborg, Gunnar ; Gutzkow, Kristine B. ; Nygaard, Unni C. ; Løvik, Martinus ; Kyrtopoulos, Soterios A. ; Segerbäck, Dan ; Merlo, Domenico F. ; Kleinjans, Jos C. ; Vrijheid, Martine ; Kogevinas, Manolis. / In utero exposure to compounds with dioxin-like activity and birth outcomes. In: Epidemiology. 2014 ; Vol. 25, No. 2. pp. 215-224.

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abstract = "BACKGROUND:: Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study. METHODS:: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference. RESULTS:: Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes. CONCLUSIONS:: Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.",

author = "Marina Vafeiadi and Silvia Agramunt and Marie Pedersen and Harrie Besselink and Leda Chatzi and Eleni Fthenou and Sarah Fleming and Hardie, {Laura J.} and John Wright and Knudsen, {Lisbeth E.} and Nielsen, {Jeanette K S} and Jordi Sunyer and Ramon Carreras and Gunnar Brunborg and Gutzkow, {Kristine B.} and Nygaard, {Unni C.} and Martinus L{\o}vik and Kyrtopoulos, {Soterios A.} and Dan Segerb{\"a}ck and Merlo, {Domenico F.} and Kleinjans, {Jos C.} and Martine Vrijheid and Manolis Kogevinas",

year = "2014",

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doi = "10.1097/EDE.0000000000000046",

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T1 - In utero exposure to compounds with dioxin-like activity and birth outcomes

AU - Vafeiadi, Marina

AU - Agramunt, Silvia

AU - Pedersen, Marie

AU - Besselink, Harrie

AU - Chatzi, Leda

AU - Fthenou, Eleni

AU - Fleming, Sarah

AU - Hardie, Laura J.

AU - Wright, John

AU - Knudsen, Lisbeth E.

AU - Nielsen, Jeanette K S

AU - Sunyer, Jordi

AU - Carreras, Ramon

AU - Brunborg, Gunnar

AU - Gutzkow, Kristine B.

AU - Nygaard, Unni C.

AU - Løvik, Martinus

AU - Kyrtopoulos, Soterios A.

AU - Segerbäck, Dan

AU - Merlo, Domenico F.

AU - Kleinjans, Jos C.

AU - Vrijheid, Martine

AU - Kogevinas, Manolis

PY - 2014/3

Y1 - 2014/3

N2 - BACKGROUND:: Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study. METHODS:: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference. RESULTS:: Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes. CONCLUSIONS:: Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.

AB - BACKGROUND:: Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study. METHODS:: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference. RESULTS:: Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes. CONCLUSIONS:: Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.

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