In utero exposure to compounds with dioxin-like activity and birth outcomes

Marina Vafeiadi, Silvia Agramunt, Marie Pedersen, Harrie Besselink, Leda Chatzi, Eleni Fthenou, Sarah Fleming, Laura J. Hardie, John Wright, Lisbeth E. Knudsen, Jeanette K S Nielsen, Jordi Sunyer, Ramon Carreras, Gunnar Brunborg, Kristine B. Gutzkow, Unni C. Nygaard, Martinus Løvik, Soterios A. Kyrtopoulos, Dan Segerbäck, Domenico F. MerloJos C. Kleinjans, Martine Vrijheid, Manolis Kogevinas

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Abstract

BACKGROUND:: Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study. METHODS:: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference. RESULTS:: Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes. CONCLUSIONS:: Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.

Original languageEnglish
Pages (from-to)215-224
Number of pages10
JournalEpidemiology
Volume25
Issue number2
DOIs
Publication statusPublished - Mar 2014

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ASJC Scopus subject areas

  • Epidemiology

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Vafeiadi, M., Agramunt, S., Pedersen, M., Besselink, H., Chatzi, L., Fthenou, E., Fleming, S., Hardie, L. J., Wright, J., Knudsen, L. E., Nielsen, J. K. S., Sunyer, J., Carreras, R., Brunborg, G., Gutzkow, K. B., Nygaard, U. C., Løvik, M., Kyrtopoulos, S. A., Segerbäck, D., ... Kogevinas, M. (2014). In utero exposure to compounds with dioxin-like activity and birth outcomes. Epidemiology, 25(2), 215-224. https://doi.org/10.1097/EDE.0000000000000046