In utero virilization by danazol: Effects on adrenal steroidogenesis

P. Picco; L. R. Garibaldi; M. Di Rocco; E. Podesta; M. Faraci; P. Levratto; M. Gattorno; S. Pang

In utero virilization by danazol: Effects on adrenal steroidogenesis

P. Picco, L. R. Garibaldi, M. Di Rocco, E. Podesta, M. Faraci, P. Levratto, M. Gattorno, S. Pang

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Adolescent and Pediatric Gynecology
Volume	8
Issue number	2
Publication status	Published - 1995

Keywords

Adrenal steroidogenesis
Androgens
Danazol
Female pseudohermaphroditism
Prenatal virilization

ASJC Scopus subject areas

Obstetrics and Gynaecology
Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.",

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T1 - In utero virilization by danazol

T2 - Effects on adrenal steroidogenesis

AU - Picco, P.

AU - Garibaldi, L. R.

AU - Di Rocco, M.

AU - Podesta, E.

AU - Faraci, M.

AU - Levratto, P.

AU - Gattorno, M.

AU - Pang, S.

PY - 1995

Y1 - 1995

N2 - The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.

AB - The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.

KW - Adrenal steroidogenesis

KW - Androgens

KW - Danazol

KW - Female pseudohermaphroditism

KW - Prenatal virilization

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AN - SCOPUS:0029065813

VL - 8

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JO - Adolescent and Pediatric Gynecology

JF - Adolescent and Pediatric Gynecology

SN - 0932-8610

IS - 2

ER -

In utero virilization by danazol: Effects on adrenal steroidogenesis

Abstract

Keywords

ASJC Scopus subject areas

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