Abstract
The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.
Original language | English |
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Pages (from-to) | 97-100 |
Number of pages | 4 |
Journal | Adolescent and Pediatric Gynecology |
Volume | 8 |
Issue number | 2 |
Publication status | Published - 1995 |
Keywords
- Adrenal steroidogenesis
- Androgens
- Danazol
- Female pseudohermaphroditism
- Prenatal virilization
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Pediatrics, Perinatology, and Child Health