In utero virilization by danazol: Effects on adrenal steroidogenesis

P. Picco, L. R. Garibaldi, M. Di Rocco, E. Podesta, M. Faraci, P. Levratto, M. Gattorno, S. Pang

Research output: Contribution to journalArticlepeer-review


The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalAdolescent and Pediatric Gynecology
Issue number2
Publication statusPublished - 1995


  • Adrenal steroidogenesis
  • Androgens
  • Danazol
  • Female pseudohermaphroditism
  • Prenatal virilization

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health


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