In vitro activation of mononuclear cells by two probiotics: Lactobacillus paracasei I 1688, Lactobacillus salivarius I 1794, and their mixture (PSMIX)

A. M. Castellazzi, C. Valsecchi, L. Montagna, P. Malfa, G. Ciprandi, M. A. Avanzini, G. L. Marseglia

Research output: Contribution to journalArticle

Abstract

Background: Most studies on probiotics have described their effects on the human immune system after ingestion of LAB, but little is known about their effect on in vitro stimulation of human immune cells. Aim of the study: Evaluate the "in vitro" activity of Lactobacillus paracasei (I 1688), Lactobacillus salivarius (I 1794), and a commercial mix of the two (PSMIX, Proge Farm), on immune cells from healthy individuals. Materials: Two probiotic strains, Lactobacillus salivarius (I 1794; Proge Farm, Italy) and Lactobacillus paracasei (I 1688; Proge Farm, Italy), which are contained in the functional food ENTEROBACILLI, were evaluated for their ability to stimulate peripheral blood mononuclear cells and modulate surface phenotype and cytokine production. Results: All subjects responded to the bacteria, with different levels of response. The cell populations that showed a significant percent increase were CD4+/CD25+ cells (T-helper activated regulatory cells), CD8+/CD25+ (T-suppressor/cytotoxic activated cells), and CD16+/CD56+ (NK cells) (p

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalImmunological Investigations
Volume36
Issue number4
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Cytokine
  • Immune response
  • Probiotics
  • T and NK Cells

ASJC Scopus subject areas

  • Immunology

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