In vitro activities of antimicrobial agents against Mycobacterium avium complex isolated from patients with acquired immunodeficiency syndrome in Northern Sardinia

S. Zanetti, P. Molicotti, G. Delogu, F. Porcu, F. Saba, A. Sanna, L. Sechi, S. Piro, G. Panichi, G. Fadda

Research output: Contribution to journalArticlepeer-review

Abstract

Multidrug therapy is recommended for the treatment of Mycobacterium avium complex in patients with AIDS. For this reason is this study we have evaluated the activity of several antimicrobial agents against different strains of Mycobacterium avium isolated from AIDS patients in Northern Sardinia. All the strains were recovered from blood cultures, and confirmed to be M. avium by Accuprobe assay. Antimicrobial MICs were determined in 7H12 broth by radiometric method. Our data demonstrated that rifabutin, ethambutol, amikacin, clarithromycin and clofazimine are the antimicrobial agents that possessed significant in vitro activity against M. avium. Radiometric assessment of two drug combinations by using established x/y determinations revealed enhanced activity when ethambutol was used in combination with rifabutin, rifampin, streptomycin, clofazimine, amikacin, claritromycin, azitromycin and ciprofloxacin.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalIgiene Moderna
Volume108
Issue number5
Publication statusPublished - Nov 1997

Keywords

  • AIDS patients
  • Antimicrobial therapy
  • Mycobacterium avium

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'In vitro activities of antimicrobial agents against Mycobacterium avium complex isolated from patients with acquired immunodeficiency syndrome in Northern Sardinia'. Together they form a unique fingerprint.

Cite this