Multidrug therapy is recommended for the treatment of Mycobacterium avium complex in patients with AIDS. For this reason is this study we have evaluated the activity of several antimicrobial agents against different strains of Mycobacterium avium isolated from AIDS patients in Northern Sardinia. All the strains were recovered from blood cultures, and confirmed to be M. avium by Accuprobe assay. Antimicrobial MICs were determined in 7H12 broth by radiometric method. Our data demonstrated that rifabutin, ethambutol, amikacin, clarithromycin and clofazimine are the antimicrobial agents that possessed significant in vitro activity against M. avium. Radiometric assessment of two drug combinations by using established x/y determinations revealed enhanced activity when ethambutol was used in combination with rifabutin, rifampin, streptomycin, clofazimine, amikacin, claritromycin, azitromycin and ciprofloxacin.
|Number of pages||8|
|Publication status||Published - Nov 1997|
- AIDS patients
- Antimicrobial therapy
- Mycobacterium avium
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health