In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens

E. Maioli, A. Marchese, S. Roveta, S. Cagnacci, F. Cavallini, C. Cassanelli, L. Gualco, E. A. Debbia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Some new features of the in vitro activity of ceftibuten, an oral third generation cephalosporin, have been studied in reference to respiratory and urinary tract pathogens included in its antibacterial spectrum. At 0.25XMIC (minimum inhibitory concentration) and 0.5XMIC levels, ceftibuten was able to affect the biofilm production in 2/3 of both Escherichia coli and Proteus mirabilis strains, and reduced the number of strains capable of adhering to epithelial cells by about 35% in comparison to the control. Surface hydrophobicity was also influenced by ceftibuten and the other drugs at 0.25-0.5XMIC. In general, no marked variation in the virulence traits of the pathogens studied were found by exposing bacteria to sub-MICs of ceftibuten. Plasmid loss (from 1.8 to 37.2%), and Flac transfer inhibition (about 30-50% reduction in the number of recombinants) were detected under the experimental conditions used. This study confirms the excellent antibacterial properties of ceftibuten by adding new information about the effects of this antibiotic against pathogens often involved in respiratory and urinary tract infections that may be treated with this compound, supporting the appropriate use of this cephalosporin.

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalJournal of Chemotherapy
Volume19
Issue number2
Publication statusPublished - Apr 2007

Fingerprint

Urinary Tract
Respiratory System
Anti-Bacterial Agents
Cephalosporins
Proteus mirabilis
Microbial Sensitivity Tests
Biofilms
Hydrophobic and Hydrophilic Interactions
Urinary Tract Infections
Respiratory Tract Infections
Virulence
Plasmids
Epithelial Cells
ceftibuten
In Vitro Techniques
Escherichia coli
Bacteria
Pharmaceutical Preparations

Keywords

  • Ceftibuten
  • Respiratory pathogens
  • Urinary pathogens

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

Maioli, E., Marchese, A., Roveta, S., Cagnacci, S., Cavallini, F., Cassanelli, C., ... Debbia, E. A. (2007). In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens. Journal of Chemotherapy, 19(2), 152-160.

In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens. / Maioli, E.; Marchese, A.; Roveta, S.; Cagnacci, S.; Cavallini, F.; Cassanelli, C.; Gualco, L.; Debbia, E. A.

In: Journal of Chemotherapy, Vol. 19, No. 2, 04.2007, p. 152-160.

Research output: Contribution to journalArticle

Maioli, E, Marchese, A, Roveta, S, Cagnacci, S, Cavallini, F, Cassanelli, C, Gualco, L & Debbia, EA 2007, 'In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens', Journal of Chemotherapy, vol. 19, no. 2, pp. 152-160.
Maioli, E. ; Marchese, A. ; Roveta, S. ; Cagnacci, S. ; Cavallini, F. ; Cassanelli, C. ; Gualco, L. ; Debbia, E. A. / In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens. In: Journal of Chemotherapy. 2007 ; Vol. 19, No. 2. pp. 152-160.
@article{87ff1ae5000d47a58a29c827a7130455,
title = "In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens",
abstract = "Some new features of the in vitro activity of ceftibuten, an oral third generation cephalosporin, have been studied in reference to respiratory and urinary tract pathogens included in its antibacterial spectrum. At 0.25XMIC (minimum inhibitory concentration) and 0.5XMIC levels, ceftibuten was able to affect the biofilm production in 2/3 of both Escherichia coli and Proteus mirabilis strains, and reduced the number of strains capable of adhering to epithelial cells by about 35{\%} in comparison to the control. Surface hydrophobicity was also influenced by ceftibuten and the other drugs at 0.25-0.5XMIC. In general, no marked variation in the virulence traits of the pathogens studied were found by exposing bacteria to sub-MICs of ceftibuten. Plasmid loss (from 1.8 to 37.2{\%}), and Flac transfer inhibition (about 30-50{\%} reduction in the number of recombinants) were detected under the experimental conditions used. This study confirms the excellent antibacterial properties of ceftibuten by adding new information about the effects of this antibiotic against pathogens often involved in respiratory and urinary tract infections that may be treated with this compound, supporting the appropriate use of this cephalosporin.",
keywords = "Ceftibuten, Respiratory pathogens, Urinary pathogens",
author = "E. Maioli and A. Marchese and S. Roveta and S. Cagnacci and F. Cavallini and C. Cassanelli and L. Gualco and Debbia, {E. A.}",
year = "2007",
month = "4",
language = "English",
volume = "19",
pages = "152--160",
journal = "Journal of Chemotherapy",
issn = "1120-009X",
publisher = "Maney Publishing",
number = "2",

}

TY - JOUR

T1 - In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens

AU - Maioli, E.

AU - Marchese, A.

AU - Roveta, S.

AU - Cagnacci, S.

AU - Cavallini, F.

AU - Cassanelli, C.

AU - Gualco, L.

AU - Debbia, E. A.

PY - 2007/4

Y1 - 2007/4

N2 - Some new features of the in vitro activity of ceftibuten, an oral third generation cephalosporin, have been studied in reference to respiratory and urinary tract pathogens included in its antibacterial spectrum. At 0.25XMIC (minimum inhibitory concentration) and 0.5XMIC levels, ceftibuten was able to affect the biofilm production in 2/3 of both Escherichia coli and Proteus mirabilis strains, and reduced the number of strains capable of adhering to epithelial cells by about 35% in comparison to the control. Surface hydrophobicity was also influenced by ceftibuten and the other drugs at 0.25-0.5XMIC. In general, no marked variation in the virulence traits of the pathogens studied were found by exposing bacteria to sub-MICs of ceftibuten. Plasmid loss (from 1.8 to 37.2%), and Flac transfer inhibition (about 30-50% reduction in the number of recombinants) were detected under the experimental conditions used. This study confirms the excellent antibacterial properties of ceftibuten by adding new information about the effects of this antibiotic against pathogens often involved in respiratory and urinary tract infections that may be treated with this compound, supporting the appropriate use of this cephalosporin.

AB - Some new features of the in vitro activity of ceftibuten, an oral third generation cephalosporin, have been studied in reference to respiratory and urinary tract pathogens included in its antibacterial spectrum. At 0.25XMIC (minimum inhibitory concentration) and 0.5XMIC levels, ceftibuten was able to affect the biofilm production in 2/3 of both Escherichia coli and Proteus mirabilis strains, and reduced the number of strains capable of adhering to epithelial cells by about 35% in comparison to the control. Surface hydrophobicity was also influenced by ceftibuten and the other drugs at 0.25-0.5XMIC. In general, no marked variation in the virulence traits of the pathogens studied were found by exposing bacteria to sub-MICs of ceftibuten. Plasmid loss (from 1.8 to 37.2%), and Flac transfer inhibition (about 30-50% reduction in the number of recombinants) were detected under the experimental conditions used. This study confirms the excellent antibacterial properties of ceftibuten by adding new information about the effects of this antibiotic against pathogens often involved in respiratory and urinary tract infections that may be treated with this compound, supporting the appropriate use of this cephalosporin.

KW - Ceftibuten

KW - Respiratory pathogens

KW - Urinary pathogens

UR - http://www.scopus.com/inward/record.url?scp=34247860661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247860661&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 152

EP - 160

JO - Journal of Chemotherapy

JF - Journal of Chemotherapy

SN - 1120-009X

IS - 2

ER -