In vitro activity of taxol and taxotere in comparison with doxorubicin and cisplatin on primary cell cultures of human breast cancers

Wainer Zoli, Alberto Flamigni, Giovanni Luca Frassineti, Paola Bajorko, Franca De Paola, Carlo Milandri, Dino Amadori, Anna Gasperi-Campani

Research output: Contribution to journalArticlepeer-review

Abstract

The in vitro activities of taxol and taxotere in comparison with cisplatin and doxorubicin were assessed in 30 primary tumor cultures from human breast cancers. Both taxanes were much more potent than cisplatin and doxorubicin. Taxotere was 3.1; 296, and 9.6-fold more cytotoxic than taxol, cisplatin, and doxorubicin respectively. The cytotoxic activity observed in our experiments confirms the potential clinical relevance of the two taxanes in the management of breast cancer.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalBreast Cancer Research and Treatment
Volume34
Issue number1
DOIs
Publication statusPublished - Apr 1995

Keywords

  • clonogenic assay
  • primary human breast cancers
  • taxol
  • taxotere

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'In vitro activity of taxol and taxotere in comparison with doxorubicin and cisplatin on primary cell cultures of human breast cancers'. Together they form a unique fingerprint.

Cite this