In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi

F. D. D'Auria, L. Laino, V. Strippoli, M. Tecca, G. Salvatore, L. Battinelli, G. Mazzanti

Research output: Contribution to journalArticle

Abstract

The antifungal activity of Melaleuca alternifolia Maiden (Myrtaceae) essential oil against yeasts (Candida spp., Schizosaccharomyces pombe, Debaryomyces hansenii) and dermatophytes (Microsporum spp. and Tricophyton spp.) is reported. We focused on the ability of tea tree oil to inhibit Candida albicans conversion from the yeast to the pathogenic mycelial form. Moreover we carried out broth microdilution test and contact tests to evaluate the killing time. M. alternifolia essential oil inhibited the conversion of C. albicans from yeast to the mycelial form at a concentration of 0.16% (v/v). The minimum inhibitory concentrations (MICs) ranged from 0.12% to 0.50% (v/v) for yeasts and 0.12% to 1% (v/v) for dermatophytes; the cytocidal activity was generally expressed at the same concentration. These results, if considered along with the lipophilic nature of the oil which enables it to penetrate the skin, suggest it may be suitable for topical therapeutic use in the treatment of fungal mucosal and cutaneous infections.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalJournal of Chemotherapy
Volume13
Issue number4
Publication statusPublished - 2001

Keywords

  • Candida albicans
  • Cytocidal activity
  • Dermatophytes
  • Germ-tube inhibition
  • Mycelial conversion
  • Tea tree oil

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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  • Cite this

    D'Auria, F. D., Laino, L., Strippoli, V., Tecca, M., Salvatore, G., Battinelli, L., & Mazzanti, G. (2001). In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi. Journal of Chemotherapy, 13(4), 377-383.