In vitro activity of teichomycin against clinical isolates of gram-positive bacteria: Preliminary results

A. Fietta, P. Mangiarotti, G. Gialdroni Grassi

Research output: Contribution to journalArticle

Abstract

The in vitro activity of teichomycin was evaluated against 189 clinical isolates of Staphylococcus aureus, Staphylococcus albus and group D streptococci. Teichomycin was as active as vancomycin, a chemically related antibiotic, on staphylococci, and inhibited the in vitro growth of methicillin-resistant strains at the same concentration necessary to inhibit the sensitive ones. Against group D streptococci teichomycin was about four times more active than vancomycin. MBC:MIC ratios of both drugs against staphylococci were comparable, but teichomycin had higher bactericidal activity against group D streptococci. The activity of teichomycin was not significantly affected by variation of pH, although the maximum activity was achieved in neutral pH. The antibiotic seemed more active when tested with low inoculum size (103-105); in fact a four-fold increase of MIC was observed with an inoculum of 107.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalDrugs under Experimental and Clinical Research
Volume10
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

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