In-vitro analyses of mechanisms of B-cell development

Antonius Rolink; Paolo Ghia; Ulf Grawunder; Dirk Haasner; Hajime Karasuyama; Christian Kalberer; Thomas Winkler; Fritz Melchers

doi:10.1016/1044-5323(95)90043-8

In-vitro analyses of mechanisms of B-cell development

Antonius Rolink, Paolo Ghia, Ulf Grawunder, Dirk Haasner, Hajime Karasuyama, Christian Kalberer, Thomas Winkler, Fritz Melchers

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

Original language	English
Pages (from-to)	155-167
Number of pages	13
Journal	Seminars in Immunology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/1044-5323(95)90043-8
Publication status	Published - 1995

Keywords

Ig-rearrangements
interleukins
pre-B cells
stromal cells
surrogate light chain

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Infectious Diseases

Access to Document

10.1016/1044-5323(95)90043-8

Cite this

@article{2f26509bea0643e1abe8b1016d3a243d,

title = "In-vitro analyses of mechanisms of B-cell development",

abstract = "B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.",

keywords = "Ig-rearrangements, interleukins, pre-B cells, stromal cells, surrogate light chain",

author = "Antonius Rolink and Paolo Ghia and Ulf Grawunder and Dirk Haasner and Hajime Karasuyama and Christian Kalberer and Thomas Winkler and Fritz Melchers",

year = "1995",

doi = "10.1016/1044-5323(95)90043-8",

language = "English",

volume = "7",

pages = "155--167",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - In-vitro analyses of mechanisms of B-cell development

AU - Rolink, Antonius

AU - Ghia, Paolo

AU - Grawunder, Ulf

AU - Haasner, Dirk

AU - Karasuyama, Hajime

AU - Kalberer, Christian

AU - Winkler, Thomas

AU - Melchers, Fritz

PY - 1995

Y1 - 1995

N2 - B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

AB - B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

KW - Ig-rearrangements

KW - interleukins

KW - pre-B cells

KW - stromal cells

KW - surrogate light chain

UR - http://www.scopus.com/inward/record.url?scp=0029320262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029320262&partnerID=8YFLogxK

U2 - 10.1016/1044-5323(95)90043-8

DO - 10.1016/1044-5323(95)90043-8

M3 - Article

C2 - 7579202

AN - SCOPUS:0029320262

VL - 7

SP - 155

EP - 167

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 3

ER -

In-vitro analyses of mechanisms of B-cell development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this