In-vitro analyses of mechanisms of B-cell development

Antonius Rolink, Paolo Ghia, Ulf Grawunder, Dirk Haasner, Hajime Karasuyama, Christian Kalberer, Thomas Winkler, Fritz Melchers

Research output: Contribution to journalArticlepeer-review


B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

Original languageEnglish
Pages (from-to)155-167
Number of pages13
JournalSeminars in Immunology
Issue number3
Publication statusPublished - 1995


  • Ig-rearrangements
  • interleukins
  • pre-B cells
  • stromal cells
  • surrogate light chain

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases


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