Abstract
B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.
Original language | English |
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Pages (from-to) | 155-167 |
Number of pages | 13 |
Journal | Seminars in Immunology |
Volume | 7 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Ig-rearrangements
- interleukins
- pre-B cells
- stromal cells
- surrogate light chain
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Infectious Diseases