In-vitro analyses of mechanisms of B-cell development

Antonius Rolink; Paolo Ghia; Ulf Grawunder; Dirk Haasner; Hajime Karasuyama; Christian Kalberer; Thomas Winkler; Fritz Melchers

doi:10.1016/1044-5323(95)90043-8

In-vitro analyses of mechanisms of B-cell development

Antonius Rolink, Paolo Ghia, Ulf Grawunder, Dirk Haasner, Hajime Karasuyama, Christian Kalberer, Thomas Winkler, Fritz Melchers

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

Original language	English
Pages (from-to)	155-167
Number of pages	13
Journal	Seminars in Immunology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/1044-5323(95)90043-8
Publication status	Published - 1995

Fingerprint

Keywords

Ig-rearrangements
interleukins
pre-B cells
stromal cells
surrogate light chain

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Infectious Diseases

Cite this

Rolink, A., Ghia, P., Grawunder, U., Haasner, D., Karasuyama, H., Kalberer, C., Winkler, T., & Melchers, F. (1995). In-vitro analyses of mechanisms of B-cell development. Seminars in Immunology, 7(3), 155-167. https://doi.org/10.1016/1044-5323(95)90043-8

@article{2f26509bea0643e1abe8b1016d3a243d,

title = "In-vitro analyses of mechanisms of B-cell development",

abstract = "B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.",

keywords = "Ig-rearrangements, interleukins, pre-B cells, stromal cells, surrogate light chain",

author = "Antonius Rolink and Paolo Ghia and Ulf Grawunder and Dirk Haasner and Hajime Karasuyama and Christian Kalberer and Thomas Winkler and Fritz Melchers",

year = "1995",

doi = "10.1016/1044-5323(95)90043-8",

language = "English",

volume = "7",

pages = "155--167",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - In-vitro analyses of mechanisms of B-cell development

AU - Rolink, Antonius

AU - Ghia, Paolo

AU - Grawunder, Ulf

AU - Haasner, Dirk

AU - Karasuyama, Hajime

AU - Kalberer, Christian

AU - Winkler, Thomas

AU - Melchers, Fritz

PY - 1995

Y1 - 1995

N2 - B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

AB - B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.

KW - Ig-rearrangements

KW - interleukins

KW - pre-B cells

KW - stromal cells

KW - surrogate light chain

UR - http://www.scopus.com/inward/record.url?scp=0029320262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029320262&partnerID=8YFLogxK

U2 - 10.1016/1044-5323(95)90043-8

DO - 10.1016/1044-5323(95)90043-8

M3 - Article

C2 - 7579202

AN - SCOPUS:0029320262

VL - 7

SP - 155

EP - 167

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 3

ER -

Access to Document

10.1016/1044-5323(95)90043-8