In vitro analysis of cell-mediated immunity: Clinical relevance

Gene M. Shearer, Mario Clerici

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cellular immunity, a major component of the immune system, contributes to protection against infections and plays a role in the rejection of foreign allografts. T helper cells and the antigen-presenting cells with which they interact provide important functions for cellular immune responses by generating helper signals via soluble molecules known as lymphokines or cytokines. As described here, in vitro analysis of markers of cellular immune function can be used for clinical diagnosis and assessment of therapeutic efficacy and to elucidate the mechanisms of immune dysregulation. Not all helper signals necessarily have the same augmenting effect, because immunoregulatory cytokines that up-regulate the cellular arm of the immune system can conversely down-regulate the humoral arm, and vice versa. The interplay between cross-regulatory cytokines determines which component of the immune system is dominant and can influence the clinical outcome of immunologically controlled diseases. Given the apparent dramatic effects of these cytokines, assays performed in future clinical laboratories should include profiles of immunoregulatory cytokines.

Original languageEnglish
Pages (from-to)2162-2165
Number of pages4
JournalClinical Chemistry
Volume40
Issue number11 II
Publication statusPublished - 1994

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Cellular Immunity
Cytokines
Immune system
Immune System
Clinical laboratories
Lymphokines
Antigen-Presenting Cells
Helper-Inducer T-Lymphocytes
Allografts
Assays
Arm
Up-Regulation
Down-Regulation
Biomarkers
In Vitro Techniques
Molecules
Infection
Therapeutics

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

In vitro analysis of cell-mediated immunity : Clinical relevance. / Shearer, Gene M.; Clerici, Mario.

In: Clinical Chemistry, Vol. 40, No. 11 II, 1994, p. 2162-2165.

Research output: Contribution to journalArticle

Shearer, Gene M. ; Clerici, Mario. / In vitro analysis of cell-mediated immunity : Clinical relevance. In: Clinical Chemistry. 1994 ; Vol. 40, No. 11 II. pp. 2162-2165.
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