In vitro and in vivo expression of somatostatin receptors in intermediate and malignant soft tissue tumors

Tullio Florio, Liliana Montella, Alessandro Corsaro, Annarosaria De Chiara, Gaetano Apice, Flavio Fazioli, Secondo Lastoria, Gennaro Schettini, Giovannella Palmieri

Research output: Contribution to journalArticle

Abstract

Background: Previous studies showed that the subtype 2 of somatostatin receptors (sstr2) is generally expressed by soft tissue sarcomas. Materials and Methods: Using reverse transcription-polymerase chain reaction (RT-PCR), the present study evaluated the expression of sstr mRNA in 31 human intermediate and malignant soft tissue tumors. In 8 patients somatostatin receptor scintigraphy was performed to detect soft tissue tumor sites and visualize in vivo sstr expression. Results: Somatostatin receptors were identified in 84% of the tumors analyzed by RT-PCR analysis. sstr1 and sstr2 were the receptors most frequently detected. Somatostatin receptor scintigraphy was able to identify primary and/or metastatic sites in 7 out of 8 patients, with an overall sensitivity per site of 87%. Concordant results were found between in vitro and in vivo techniques. Conclusion: The wide expression of sstrs in soft tissue tumors suggest a relevant role for these receptors in diagnosis and may have therapeutic applications.

Original languageEnglish
Pages (from-to)2465-2471
Number of pages7
JournalAnticancer Research
Volume23
Issue number3 B
Publication statusPublished - May 2003

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Keywords

  • Octreotide
  • RT-PCR
  • Soft tissue tumors
  • Somatostatin receptor
  • Somatostatin receptor scintigraphy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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