Abstract
Background: Previous studies showed that the subtype 2 of somatostatin receptors (sstr2) is generally expressed by soft tissue sarcomas. Materials and Methods: Using reverse transcription-polymerase chain reaction (RT-PCR), the present study evaluated the expression of sstr mRNA in 31 human intermediate and malignant soft tissue tumors. In 8 patients somatostatin receptor scintigraphy was performed to detect soft tissue tumor sites and visualize in vivo sstr expression. Results: Somatostatin receptors were identified in 84% of the tumors analyzed by RT-PCR analysis. sstr1 and sstr2 were the receptors most frequently detected. Somatostatin receptor scintigraphy was able to identify primary and/or metastatic sites in 7 out of 8 patients, with an overall sensitivity per site of 87%. Concordant results were found between in vitro and in vivo techniques. Conclusion: The wide expression of sstrs in soft tissue tumors suggest a relevant role for these receptors in diagnosis and may have therapeutic applications.
Original language | English |
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Pages (from-to) | 2465-2471 |
Number of pages | 7 |
Journal | Anticancer Research |
Volume | 23 |
Issue number | 3 B |
Publication status | Published - May 2003 |
Keywords
- Octreotide
- RT-PCR
- Soft tissue tumors
- Somatostatin receptor
- Somatostatin receptor scintigraphy
ASJC Scopus subject areas
- Cancer Research
- Oncology