In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs

Marina Viora, Andrea De Luca, Antonella D'Ambrosio, Andrea Antinori, Elena Ortona

Research output: Contribution to journalArticlepeer-review

Abstract

The anti-Pneumocystis carinii drug effects on mitogen-, antigen-, and interleukin-2-induced proliferative responses and on natural killer (NK) cell-mediated activity were analyzed in vivo (rats) and in vitro (normal human peripheral blood mononuclear cells). Splenocytes derived from in vivo piritrexim- and clindamycin-treated rats showed a significant inhibition of mitogen-induced proliferative responses. In vitro exposure to clindamycin, piritrexim, and pyrimethamine caused an inhibition of human T lymphocyte proliferation in response to mitogen, antigen, and interleukin-2-stimulation. Rat NK cell-mediated cytotoxic activity was not affected by the drugs, and human NK cell activity was reduced only at the highest concentration (10 μg/ml) of the drugs. The potential immunotoxicity of the long-term administration of these agents in humans needs further investigation.

Original languageEnglish
Pages (from-to)1294-1297
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume40
Issue number5
Publication statusPublished - May 1996

ASJC Scopus subject areas

  • Pharmacology (medical)

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