The anti-Pneumocystis carinii drug effects on mitogen-, antigen-, and interleukin-2-induced proliferative responses and on natural killer (NK) cell-mediated activity were analyzed in vivo (rats) and in vitro (normal human peripheral blood mononuclear cells). Splenocytes derived from in vivo piritrexim- and clindamycin-treated rats showed a significant inhibition of mitogen-induced proliferative responses. In vitro exposure to clindamycin, piritrexim, and pyrimethamine caused an inhibition of human T lymphocyte proliferation in response to mitogen, antigen, and interleukin-2-stimulation. Rat NK cell-mediated cytotoxic activity was not affected by the drugs, and human NK cell activity was reduced only at the highest concentration (10 μg/ml) of the drugs. The potential immunotoxicity of the long-term administration of these agents in humans needs further investigation.
|Number of pages||4|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - May 1996|
ASJC Scopus subject areas
- Pharmacology (medical)