In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs

Marina Viora, Andrea De Luca, Antonella D'Ambrosio, Andrea Antinori, Elena Ortona

Research output: Contribution to journalArticle

Abstract

The anti-Pneumocystis carinii drug effects on mitogen-, antigen-, and interleukin-2-induced proliferative responses and on natural killer (NK) cell-mediated activity were analyzed in vivo (rats) and in vitro (normal human peripheral blood mononuclear cells). Splenocytes derived from in vivo piritrexim- and clindamycin-treated rats showed a significant inhibition of mitogen-induced proliferative responses. In vitro exposure to clindamycin, piritrexim, and pyrimethamine caused an inhibition of human T lymphocyte proliferation in response to mitogen, antigen, and interleukin-2-stimulation. Rat NK cell-mediated cytotoxic activity was not affected by the drugs, and human NK cell activity was reduced only at the highest concentration (10 μg/ml) of the drugs. The potential immunotoxicity of the long-term administration of these agents in humans needs further investigation.

Original languageEnglish
Pages (from-to)1294-1297
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume40
Issue number5
Publication statusPublished - May 1996

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Pneumocystis carinii
Mitogens
Natural Killer Cells
Clindamycin
Pharmaceutical Preparations
Interleukin-2
Antigens
Pyrimethamine
Blood Cells
T-Lymphocytes
In Vitro Techniques
piritrexim

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs. / Viora, Marina; De Luca, Andrea; D'Ambrosio, Antonella; Antinori, Andrea; Ortona, Elena.

In: Antimicrobial Agents and Chemotherapy, Vol. 40, No. 5, 05.1996, p. 1294-1297.

Research output: Contribution to journalArticle

Viora, M, De Luca, A, D'Ambrosio, A, Antinori, A & Ortona, E 1996, 'In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs', Antimicrobial Agents and Chemotherapy, vol. 40, no. 5, pp. 1294-1297.
Viora, Marina ; De Luca, Andrea ; D'Ambrosio, Antonella ; Antinori, Andrea ; Ortona, Elena. / In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs. In: Antimicrobial Agents and Chemotherapy. 1996 ; Vol. 40, No. 5. pp. 1294-1297.
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