Abstract
The effect of cyclic nucleotide phosphodieterase (PDE) inhibitors Zaprinast and DC-TA-46 has been tested on SK-N-MC neuroblastoma growth. Antiproliferative activity of the tested drugs was assayed both in vitro and in the xenograft model of nude mice. In clonal density experiments, the IC50 value was 3.3 μM for Zaprinast and 1.9 μM for DC-TA-46, while 7.5 μM BCNU alkylating agent was required to obtain the same effect. SK-N-MC cells xenografted in the nude mouse showed that the administration of Zaprinast and DC-TA-46 caused a significant 50% decrease of the tumour weight. These data demonstrate that PDE inhibitors may be useful for at least reducing tumour growth; they may be of interest for further evaluation as alternative molecules in the design of multiple agent protocols for neuroblastoma treatment.
Original language | English |
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Pages (from-to) | 25-31 |
Number of pages | 7 |
Journal | Journal of Neuro-Oncology |
Volume | 51 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Cyclic nucleotide phosphodiesterase
- DC-TA-46
- Growth inhibition
- Human neuroblastoma
- Nude mice
- Zaprinast
ASJC Scopus subject areas
- Clinical Neurology
- Cancer Research
- Oncology
- Neuroscience(all)