In vitro and in vivo performance of a novel surface treatment to enhance osseointegration of endosseous implants

Roberto Chiesa, Gianluca Giavaresi, Milena Fini, Enrico Sandrini, Carmen Giordano, Andrea Bianchi, Roberto Giardino

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This article shows the in vitro and in vivo characterization of a new biomimetic treatment developed to enhance the osseointegration of titanium dental implants. Study design: A novel biomimetic treatment of titanium was developed. Its physicochemical properties and biologic and in vivo performance were considered and studied. Mineralization capability was assessed by soaking test in simulated body fluid solution, and cytocompatibility was assessed using osteoblast-like MG63 cell culture. Histomorphometric analysis was performed at 3 time points using a sheep animal model. Results: In vitro tests confirmed the biomimetic potential of the considered novel treatment. Histomorphometric analysis indicated its potential for rapid and good-quality osseointegration. Conclusion: The in vitro and in vivo test results indicated that the proposed novel treatment possesses a significant potential to increase the rate of osteointegration of titanium for endosseous dental implants.

Original languageEnglish
Pages (from-to)745-756
Number of pages12
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume103
Issue number6
DOIs
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery
  • Otorhinolaryngology
  • Oral Surgery

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