Abstract
The cytotoxic and anti-Mycobacterium tuberculosis H37Rv activities of hydro-alcoholic extract of Lannea acida A. Rich (Anacardiaceae) were assessed. The cytoxicity evaluation was carried out on THP1 monocytoid cell line (after 24 h at 1; 5 and 10 ug mL_1) and showed only a slight modification of lactate dehydrogenase (LDH) release. The rate of monocytes in different stages of mitosis had been amended in absence and presence of extract as follows: Go/Gl 58.83 - 59.83%; synthesis 21.95 - 18.64%; mitosis 16.67 -15.77%; necrosis 2.65 - 5.64%. The percentage of inhibition of Mycobacterium tuberculosis proliferation was respectively 77.6 and 36.8% at 1.2 and 0.6 mg mL_1 of extract. This is an interesting experimental study on antimicrobial and immune-stimulating properties of Lannea acida ethanol-water (70%v/v) extract which may contain potential antibacterial and immune-stimulating agents for clinical use.
Original language | English |
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Pages (from-to) | 47-52 |
Number of pages | 6 |
Journal | Pakistan Journal of Biological Sciences |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Anacardiaceae
- Anti mycobacterium tuberculosis h37rv
- Cytotoxicity
- Ethanolic extract
- Lannea acida barks
ASJC Scopus subject areas
- Agronomy and Crop Science