In vitro anti mycobacterium tuberculosis H37Rv activity of Lannea acida a. rich from Burkina Faso

L. Ouattara, J. Koudou, D. S. Karou, L. Giaco, G. Capelli, J. Simpore, M. Fraziano, V. Colizzi, A. S. Traore

Research output: Contribution to journalArticlepeer-review

Abstract

The cytotoxic and anti-Mycobacterium tuberculosis H37Rv activities of hydro-alcoholic extract of Lannea acida A. Rich (Anacardiaceae) were assessed. The cytoxicity evaluation was carried out on THP1 monocytoid cell line (after 24 h at 1; 5 and 10 ug mL_1) and showed only a slight modification of lactate dehydrogenase (LDH) release. The rate of monocytes in different stages of mitosis had been amended in absence and presence of extract as follows: Go/Gl 58.83 - 59.83%; synthesis 21.95 - 18.64%; mitosis 16.67 -15.77%; necrosis 2.65 - 5.64%. The percentage of inhibition of Mycobacterium tuberculosis proliferation was respectively 77.6 and 36.8% at 1.2 and 0.6 mg mL_1 of extract. This is an interesting experimental study on antimicrobial and immune-stimulating properties of Lannea acida ethanol-water (70%v/v) extract which may contain potential antibacterial and immune-stimulating agents for clinical use.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalPakistan Journal of Biological Sciences
Volume14
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Anacardiaceae
  • Anti mycobacterium tuberculosis h37rv
  • Cytotoxicity
  • Ethanolic extract
  • Lannea acida barks

ASJC Scopus subject areas

  • Agronomy and Crop Science

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