In vitro assessment of lymphocytes response following re-exposure to silicone

G. Ciapetti, D. Granchi, S. Stea, E. Cenni, M. E. Donati, A. Pizzoferrato, P. Schiavon, R. Giuliani

Research output: Contribution to journalArticlepeer-review


Currently, the use of silicone-filled devices, mainly in plastic surgery for breast reconstruction or augmentation, is being debated by the scientific community in connection with the risk to the patient. In this study the response of whole blood or isolated peripheral blood lymphocytes from patients with silicone-gel-filled breast implants was assessed in vitro, in order to verify the hypothesis of silicone material acting in vivo as a sensitizing agent. Both quantitative and qualitative changes of lymphocyte subpopulations of patients carrying silicone devices were assessed and compared with healthy subjects. Upon 24-72 h in vitro re-exposure of patients' lymphocytes to silicone extract, lymphocyte surface antigen expression was monitored by flow cytometry, and the functional response of lymphocytes was measured by radioactive tracer uptake and biochemical changes.

Original languageEnglish
Pages (from-to)640-643
Number of pages4
JournalJournal of Materials Science: Materials in Medicine
Issue number9-10
Publication statusPublished - Sep 1994

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering(all)
  • Biophysics


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