In vitro binding profile of cyprodyme, a reported mu-opioid antagonist

G. Porini, P. Petrillo, M. Colombo, A. Tavani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In rat brain homogenates the reported μ-antagonist cyprodime was 46 and 42 times more active at μ- than at δ- and κ-sites. Simultaneous LIGAND analysis of [3H]-[D-Ala2MePhe4,Gly-ol5]enkephalin (DAGO) saturation and displacement curves by cyprodime, morphine and DAGO supported the existence of two μ-subtypes.

Original languageEnglish
Title of host publicationNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages225
Number of pages1
ISBN (Print)044481213X
Publication statusPublished - 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

ASJC Scopus subject areas

  • Medicine(all)

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    Porini, G., Petrillo, P., Colombo, M., & Tavani, A. (1990). In vitro binding profile of cyprodyme, a reported mu-opioid antagonist. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 225). Elsevier Science Publishers B.V..