In vitro binding profile of cyprodyme, a reported mu-opioid antagonist

G. Porini; P. Petrillo; M. Colombo; A. Tavani

In vitro binding profile of cyprodyme, a reported mu-opioid antagonist

G. Porini, P. Petrillo, M. Colombo, A. Tavani

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In rat brain homogenates the reported μ-antagonist cyprodime was 46 and 42 times more active at μ- than at δ- and κ-sites. Simultaneous LIGAND analysis of [³H]-[D-Ala²MePhe⁴,Gly-ol⁵]enkephalin (DAGO) saturation and displacement curves by cyprodime, morphine and DAGO supported the existence of two μ-subtypes.

Original language	English
Title of host publication	New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
Editors	J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
Publisher	Elsevier Science Publishers B.V.
Pages	225
Number of pages	1
ISBN (Print)	044481213X
Publication status	Published - 1990
Event	The International Narcotics Research Conference - Duration: Jul 8 1989 → Jul 13 1989

Other

Other	The International Narcotics Research Conference
Period	7/8/89 → 7/13/89

ASJC Scopus subject areas

Medicine(all)

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Porini, G., Petrillo, P., Colombo, M., & Tavani, A. (1990). In vitro binding profile of cyprodyme, a reported mu-opioid antagonist. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 225). Elsevier Science Publishers B.V..

In vitro binding profile of cyprodyme, a reported mu-opioid antagonist. / Porini, G.; Petrillo, P.; Colombo, M.; Tavani, A.

New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 225.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Porini, G, Petrillo, P, Colombo, M & Tavani, A 1990, In vitro binding profile of cyprodyme, a reported mu-opioid antagonist. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V., pp. 225, The International Narcotics Research Conference, 7/8/89.

Porini G, Petrillo P, Colombo M, Tavani A. In vitro binding profile of cyprodyme, a reported mu-opioid antagonist. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 225

Porini, G. ; Petrillo, P. ; Colombo, M. ; Tavani, A. / In vitro binding profile of cyprodyme, a reported mu-opioid antagonist. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 225

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title = "In vitro binding profile of cyprodyme, a reported mu-opioid antagonist",

abstract = "In rat brain homogenates the reported μ-antagonist cyprodime was 46 and 42 times more active at μ- than at δ- and κ-sites. Simultaneous LIGAND analysis of [3H]-[D-Ala2MePhe4,Gly-ol5]enkephalin (DAGO) saturation and displacement curves by cyprodime, morphine and DAGO supported the existence of two μ-subtypes.",

author = "G. Porini and P. Petrillo and M. Colombo and A. Tavani",

year = "1990",

language = "English",

isbn = "044481213X",

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editor = "{Van Ree}, J.M. and A.H. Mulder and V.M. Wiegant and {Van Wimersma Greidanus}, T.B. and {Van Ree}, J.M. and A.H. Mulder and V.M. Wiegant and {Van Wimersma Greidanus}, T.B.",

booktitle = "New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914",

publisher = "Elsevier Science Publishers B.V.",

note = "The International Narcotics Research Conference ; Conference date: 08-07-1989 Through 13-07-1989",

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AU - Petrillo, P.

AU - Colombo, M.

AU - Tavani, A.

PY - 1990

Y1 - 1990

N2 - In rat brain homogenates the reported μ-antagonist cyprodime was 46 and 42 times more active at μ- than at δ- and κ-sites. Simultaneous LIGAND analysis of [3H]-[D-Ala2MePhe4,Gly-ol5]enkephalin (DAGO) saturation and displacement curves by cyprodime, morphine and DAGO supported the existence of two μ-subtypes.

AB - In rat brain homogenates the reported μ-antagonist cyprodime was 46 and 42 times more active at μ- than at δ- and κ-sites. Simultaneous LIGAND analysis of [3H]-[D-Ala2MePhe4,Gly-ol5]enkephalin (DAGO) saturation and displacement curves by cyprodime, morphine and DAGO supported the existence of two μ-subtypes.

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M3 - Conference contribution

AN - SCOPUS:0025038962

SN - 044481213X

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BT - New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

A2 - Van Ree, J.M.

A2 - Mulder, A.H.

A2 - Wiegant, V.M.

A2 - Van Wimersma Greidanus, T.B.

A2 - Van Ree, J.M.

A2 - Mulder, A.H.

A2 - Wiegant, V.M.

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PB - Elsevier Science Publishers B.V.

T2 - The International Narcotics Research Conference

Y2 - 8 July 1989 through 13 July 1989

ER -

In vitro binding profile of cyprodyme, a reported mu-opioid antagonist

Abstract

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ASJC Scopus subject areas

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