The fate of apo C-II, apo C-III and apo B during the in vitro catabolism of human very low density lipoproteins (VLDL) by the action of purified lipoprotein lipase was studied. Up to 58 percent of triglyceride apo C-II and C-III was released from VLDL during hydrolysis and at a similar rate. The amount of C apoproteins lost was proportional to triglyceride hydrolysis. The apo B content of VLDL remained constant. From these studies we conclude that during the hydrolysis of human VLDL, lipoprotein lipase, while inducing a net loss of apo C, is not responsible for major changes in the apo C-II/C-III ratio.
|Number of pages||9|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine