In vitro catabolism of human very low density lipoproteins: Fate of apoproteins B and C

A. L. Catapano, A. Capurso, P. K J Kinnunen

Research output: Contribution to journalArticlepeer-review

Abstract

The fate of apo C-II, apo C-III and apo B during the in vitro catabolism of human very low density lipoproteins (VLDL) by the action of purified lipoprotein lipase was studied. Up to 58 percent of triglyceride apo C-II and C-III was released from VLDL during hydrolysis and at a similar rate. The amount of C apoproteins lost was proportional to triglyceride hydrolysis. The apo B content of VLDL remained constant. From these studies we conclude that during the hydrolysis of human VLDL, lipoprotein lipase, while inducing a net loss of apo C, is not responsible for major changes in the apo C-II/C-III ratio.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalArtery
Volume9
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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