Colture in vitro di cellule spleniche di topo - Risposta anticorpale e sintesi degli acidi nucleici

Translated title of the contribution: In vitro cell cultures of the spleen of the mouse - Antibody response and synthesis of nucleic acids

Research output: Contribution to journalArticle

Abstract

Spleen cell cultures from immunized and control mice have been followed in their morphological evolution, especially towards "blastoid" and binucleated cells. The immunological activity of cultures from immunized mice has been tested at different ages of culture by the Jerne antibody plaque essay. The ability of spleen cells to synthetize antibody was maintained in vitro for 15 days. DNA and RNA synthesis have been studied by radioautography using thymidine and uridine as precursors, respectively. No differences in the kinetic of synthesis appeared by relating the two types of cultures.

Translated title of the contributionIn vitro cell cultures of the spleen of the mouse - Antibody response and synthesis of nucleic acids
Original languageItalian
Pages (from-to)364-377
Number of pages14
JournalZeitschrift für Zellforschung und Mikroskopische Anatomie
Volume98
Issue number3
DOIs
Publication statusPublished - Sep 1969

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

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