In vitro cytotoxicity of peptichemio compared to melphalan and meta-DL-sarcolysin

L. Morasca, E. Erba

Research output: Contribution to journalArticle

Abstract

The cytotoxic activity of peptichemio was studied on primary cultures of Lewis lung carcinoma. Since peptichemio is a preparation of several peptides containing meta-L-sarcolysin, two control experiments were run with melphalan as representative of the clinically active phenylalanine mustard derivative, and meta-DL-sarcolysin, racemic form of the phenylalanine mustard derivative, included in the composition of peptichemio. Peptichemio was more active than the other two compounds and its cytotoxic activity cannot be explained merely in terms of the phenylalanine mustard the preparation contains.

Original languageEnglish
Pages (from-to)1105-1109
Number of pages5
JournalEuropean Journal of Cancer and Clinical Oncology
Volume16
Issue number8
Publication statusPublished - 1980

    Fingerprint

ASJC Scopus subject areas

  • Oncology

Cite this