Abstract
The cytotoxic activity of peptichemio was studied on primary cultures of Lewis lung carcinoma. Since peptichemio is a preparation of several peptides containing meta-L-sarcolysin, two control experiments were run with melphalan as representative of the clinically active phenylalanine mustard derivative, and meta-DL-sarcolysin, racemic form of the phenylalanine mustard derivative, included in the composition of peptichemio. Peptichemio was more active than the other two compounds and its cytotoxic activity cannot be explained merely in terms of the phenylalanine mustard the preparation contains.
| Original language | English |
|---|---|
| Pages (from-to) | 1105-1109 |
| Number of pages | 5 |
| Journal | European Journal of Cancer and Clinical Oncology |
| Volume | 16 |
| Issue number | 8 |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Oncology
Cite this
Morasca, L., & Erba, E. (1980). In vitro cytotoxicity of peptichemio compared to melphalan and meta-DL-sarcolysin. European Journal of Cancer and Clinical Oncology, 16(8), 1105-1109.