Juvenile-onset diabetics (JOD) have a significantly low peripheral T-lymphocyte count. In vitro exposure of diabetic lymphocyte cultures to insulin causes a significant T-cell count increase and thereafter no significant difference is detectable among JOD, maturity-onset diabetic (MOD) and normal subject (NS) T-cell counts. This finding supports the hypothesis that the T-lymphocyte depressed function present in JOD is a secondary phenomenon due to in vivo insulin deficiency. Possible mechanisms of insulin action in restoring E-rosette function are discussed.
|Number of pages||5|
|Journal||Bollettino dell'Istituto Sieroterapico Milanese|
|Publication status||Published - 1977|
ASJC Scopus subject areas