In vitro effect of insulin on peripheral T lymphocyte E rosette function from normal and diabetic subjects

R. Cattaneo, V. Saibene, A. Margonato, G. Pozza

Research output: Contribution to journalArticle

Abstract

Juvenile-onset diabetics (JOD) have a significantly low peripheral T-lymphocyte count. In vitro exposure of diabetic lymphocyte cultures to insulin causes a significant T-cell count increase and thereafter no significant difference is detectable among JOD, maturity-onset diabetic (MOD) and normal subject (NS) T-cell counts. This finding supports the hypothesis that the T-lymphocyte depressed function present in JOD is a secondary phenomenon due to in vivo insulin deficiency. Possible mechanisms of insulin action in restoring E-rosette function are discussed.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume56
Issue number2
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'In vitro effect of insulin on peripheral T lymphocyte E rosette function from normal and diabetic subjects'. Together they form a unique fingerprint.

  • Cite this