In vitro effect of lymphoblastoid α-interferon on subpopulations of effector cells mediating cytotoxicity for autologous hepatocytes in hepatitis B and non-A, non-B

Mario U. Mondelli, Alfredo Alberti, Giuseppe Realdi, E. Guido Rondanelli

Research output: Contribution to journalArticlepeer-review

Abstract

Controlled clinical trials are currently under way to assess the efficacy of interferon (IFN) in hepatitis B virus (HBV) infection. In the present study, T-enriched and non-T-enriched lymphocytes from six patients with acute and six patients with chronic HBV infection were cocultured with autologous liver cells with and without α-IFN (lymphoblastoid) at a concentration of 1000 U/ml of culture medium, in an 18 h cytotoxicity assay. IFN produced a significant enhancement of non-T-cell cytotoxicity in patients with acute and chronic HBV infection, from 34.3 ± 19.6% to 60.0 ± 11.2%, P

Original languageEnglish
Pages (from-to)887-891
Number of pages5
JournalInternational Journal of Immunopharmacology
Volume8
Issue number8
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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