In vitro effect of synthetic flavanoids on astrovirus infection

Fabiana Superti, Lucilla Seganti, Nicola Orsi, Nicoletta Desideri, Maria Luisa Stein, Antonella Tinari, Maria Luisa Marziano, Gianfranco Donelli

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we investigated the activity of halogeno-, cyano- and amidino-isoflavenes, isoflavans and flavans on the multiplication of human astroviruses. These are naked small round viruses which have been recognized as causative agents of human gastroenteritis, and whose capsid proteins are similar to those of picornaviruses. Although all drugs tested caused a dose-dependent reduction of viral antigen synthesis as monitored by immunofluorescence, the chloro derivatives were the most effective.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalAntiviral Research
Volume13
Issue number4
DOIs
Publication statusPublished - 1990

Keywords

  • Astrovirus
  • Synthetic flavanoid

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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