In vitro effectiveness of povidone-iodine on Acanthamoeba isolates from human cornea

Simonetta Gatti, Claudia Cevini, Antonella Bruno, Gabriella Penso, Paolo Rama, Massimo Scaglia

Research output: Contribution to journalArticle

Abstract

Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious topical and systemic drugs. We evaluated the in vitro effectiveness of povidone-iodine (PVP-I [Betadine]), an agent with broad antibacterial and antiviral activity, compared to that of chlorhexidine (CXD), a cationic antiseptic, on Acanthamoeba isolates from patients with amebic keratitis. The results showed that PVP-I solution from 0.5 to 2.5% has a better antiamebic activity both on trophic and cystic stages of Acanthamoeba spp. than does CXD.

Original languageEnglish
Pages (from-to)2232-2234
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number9
Publication statusPublished - Sep 1998

ASJC Scopus subject areas

  • Pharmacology (medical)

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