In vitro effects of cyclosporine A on allogeneic and autologous lymphocyte stimulation: Influence of HLA phenotypes

R. Scorza, M. Vanoli, A. Cigognini, G. Fabio, B. De Bernardi, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies of CsA-induced inhibition of alloreactivity demonstrated that there are wide interindividual variations in sensitivity to the drug. We have investigated whether or not this variability is associated with the individual HLA phenotype. We used the in vitro allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR), which are well established models for the recognition phase of allograft rejection and for cell cooperation between different lymphocyte subpopulations.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalTransplantation Proceedings
Volume20
Issue number2 SUPPL. 2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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