TY - JOUR
T1 - In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects
T2 - A regulatory role for zinc
AU - Paganelli, Roberto
AU - Buttari, Brigitta
AU - Camera, Emanuela
AU - Del'Anna, Maria Lucia
AU - Mastrofrancesco, Arianna
AU - Di Giampaolo, Luca
AU - Reale, Marcella
AU - Schiavone, Cosima
AU - Verna, Nicola
AU - Di Gioacchino, Mario
AU - Sabbioni, Enrico
AU - Boscolo, Paolo
AU - Picardo, Mauro
PY - 2003
Y1 - 2003
N2 - Nickel hypersensitivity represents a very common human disease state, mainly occurring in females, defined as allergic contact dermatitis. Ni is a transition metal whose activity may be modulated by congeners. Zinc, an essential component for living organisms, has been shown to counteract Ni effects in patients with Ni hypersensitivity. We analysed immune responses to both Ni and Zn in healthy subjects and patients with allergic contact dermatitis to Ni. Our in vitro results show that Ni modulates surface receptors expression, reduces phytohemagglutinin (PHA)-driven lymphoproliferation, and upregulates some proinflammatory cytokines production, including interferon (IFN)-gamma. Zn also induced CD4+ lymphocyte proliferation, but it abolished or reduced most Ni-mediated effects. Our data are consistent with the hypothesis that Zn and Ni, as part of the heavy transition metals, may exchange roles in immune-mediated phenomena leading to expression of allergic contact dermatitis.
AB - Nickel hypersensitivity represents a very common human disease state, mainly occurring in females, defined as allergic contact dermatitis. Ni is a transition metal whose activity may be modulated by congeners. Zinc, an essential component for living organisms, has been shown to counteract Ni effects in patients with Ni hypersensitivity. We analysed immune responses to both Ni and Zn in healthy subjects and patients with allergic contact dermatitis to Ni. Our in vitro results show that Ni modulates surface receptors expression, reduces phytohemagglutinin (PHA)-driven lymphoproliferation, and upregulates some proinflammatory cytokines production, including interferon (IFN)-gamma. Zn also induced CD4+ lymphocyte proliferation, but it abolished or reduced most Ni-mediated effects. Our data are consistent with the hypothesis that Zn and Ni, as part of the heavy transition metals, may exchange roles in immune-mediated phenomena leading to expression of allergic contact dermatitis.
KW - Allergic contact dermatitis
KW - Cytokines
KW - Nickel
KW - T lymphocytes
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M3 - Article
C2 - 14650623
AN - SCOPUS:10744229846
VL - 17
SP - 11
EP - 15
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
SN - 0946-672X
IS - SUPPL. 1
ER -