In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: A regulatory role for zinc

Roberto Paganelli, Brigitta Buttari, Emanuela Camera, Maria Lucia Del'Anna, Arianna Mastrofrancesco, Luca Di Giampaolo, Marcella Reale, Cosima Schiavone, Nicola Verna, Mario Di Gioacchino, Enrico Sabbioni, Paolo Boscolo, Mauro Picardo

Research output: Contribution to journalArticlepeer-review

Abstract

Nickel hypersensitivity represents a very common human disease state, mainly occurring in females, defined as allergic contact dermatitis. Ni is a transition metal whose activity may be modulated by congeners. Zinc, an essential component for living organisms, has been shown to counteract Ni effects in patients with Ni hypersensitivity. We analysed immune responses to both Ni and Zn in healthy subjects and patients with allergic contact dermatitis to Ni. Our in vitro results show that Ni modulates surface receptors expression, reduces phytohemagglutinin (PHA)-driven lymphoproliferation, and upregulates some proinflammatory cytokines production, including interferon (IFN)-gamma. Zn also induced CD4+ lymphocyte proliferation, but it abolished or reduced most Ni-mediated effects. Our data are consistent with the hypothesis that Zn and Ni, as part of the heavy transition metals, may exchange roles in immune-mediated phenomena leading to expression of allergic contact dermatitis.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Volume17
Issue numberSUPPL. 1
Publication statusPublished - 2003

Keywords

  • Allergic contact dermatitis
  • Cytokines
  • Nickel
  • T lymphocytes

ASJC Scopus subject areas

  • Biochemistry
  • Public Health, Environmental and Occupational Health

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