In vitro effects of polyphenols on the peripheral immune responses in nickel-sensitized patients

Thea Magrone, Paolo Romita, Pietro Verni, Rosaria Salvatore, Anna Spagnoletta, Manrico Magrone, Matteo A. Russo, Emilio Jirillo, Caterina Foti

Research output: Contribution to journalArticlepeer-review


Background: Nickel (Ni) is a metal largely present in the environment and prolonged exposure to it may lead to multiple pathological conditions in human subjects. Among these, the most frequent is allergic contact dermatitis. Methods: Peripheral blood mononuclear cells isolated from 25 patients with Ni-dependent contact dermatitis were evaluated in terms of cytokine release and nitric oxide (NO) production in the presence or absence of two doses (3 and 5 µg, respectively) of polyphenols. Results: Polyphenols were able to reduce the increased release of interferon-µ and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17. At the same time, exaggerated release of NO was reduced by polyphenol supplementation. Conclusion: In view of their anti-inflammatory activities, polyphenols may represent a potential therapeutic tool to treat Ni-sensitized patients.

Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalEndocrine, Metabolic and Immune Disorders - Drug Targets
Issue number4
Publication statusPublished - Jan 1 2017


  • Allergic contact dermatitis
  • Interleukin
  • Nickel
  • Nitric oxide
  • Peripheral blood mononuclear cells
  • Polyphenols

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy


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