In vitro enhancement of SAOS-2 cell calcified matrix deposition onto radio frequency magnetron sputtered bioglass-coated titanium scaffolds

Enrica Saino, Valentina Maliardi, Eliana Quartarone, Lorenzo Fassina, Laura Benedetti, Maria Gabriella Cusella De Angelis, Piercarlo Mustarelli, Alessandro Facchini, Livia Visai

Research output: Contribution to journalArticlepeer-review

Abstract

In bone tissue engineering, bioglass coating of titanium (Ti) scaffolds has drawn attention as a method to improve osteointegration and implant fixation. In this in vitro study, bioactive glass layers with an approximate thickness of 1μm were deposited at 200°C onto a three-dimensional Ti-6Al-4V scaffold using a radio frequency (r.f.) magnetron sputtering system. After incubation with SAOS-2 human osteoblasts, in comparison with the uncoated scaffolds, the bioglass-coated scaffolds showed a twofold increase in cell proliferation (p6, and enhanced the deposition of extracellular matrix components such as decorin, fibronectin, osteocalcin, osteonectin, osteopontin, and type-I and-III collagens (p

Original languageEnglish
Pages (from-to)995-1008
Number of pages14
JournalTissue Engineering - Part A
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials
  • Medicine(all)

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