Background: Probiotics have been proposed as a treatment for a lot of discomforts, both in children and adult patients. Obiective: To evaluate the in vitro activity of a food supplement containing three probiotics on the release of cytokines from immune cells of healthy individuals. Materials: The ability of three different probiotic strains (L. plantarum P17630, L. paracasei I1688 and L. salivarius I1794) in a ratio of 200:4.9:0.1 to stimulate the release of five cytokines (IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma) from peripheral blood mononuclear cells was evaluated at 24 h and 6 days. Results: An increase in expression compared to basal level was observed for IL-10, IL-12 and IFN-gamma at 24 h and 6 days after exposure to probiotics with a different time pattern. No significant increase was observed for TNF-alpha and IL-6. Conclusion: The probiotics used in this study are able to evoke a specific immune response in human lymphocytes with prevalence of anti-inflammatory cytokines and IFN-gamma.
|Translated title of the contribution||In vitro evaluation of immunomodulating activity of a food supplement containing three probiotics: L. plantarum P17630, L. paracasei I1688, L. salivarius I1794|
|Number of pages||7|
|Journal||Trends in Medicine|
|Publication status||Published - Jan 2010|
ASJC Scopus subject areas
- Internal Medicine
- Pharmacology (medical)