Valutazione in vitro dell'attività immunomodulante di un integratore alimentare costituito da una miscela di tre specifici ceppi probiotici: L. plantarum P17630, L. paracasei I1688 e L. salivarius I1794

Translated title of the contribution: In vitro evaluation of immunomodulating activity of a food supplement containing three probiotics: L. plantarum P17630, L. paracasei I1688, L. salivarius I1794

Patrizia Malfa, Chiara Valsecchi, Lorenza Montagna, Melissa Mantelli, Annamaria Castellazzi

Research output: Contribution to journalArticle

Abstract

Background: Probiotics have been proposed as a treatment for a lot of discomforts, both in children and adult patients. Obiective: To evaluate the in vitro activity of a food supplement containing three probiotics on the release of cytokines from immune cells of healthy individuals. Materials: The ability of three different probiotic strains (L. plantarum P17630, L. paracasei I1688 and L. salivarius I1794) in a ratio of 200:4.9:0.1 to stimulate the release of five cytokines (IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma) from peripheral blood mononuclear cells was evaluated at 24 h and 6 days. Results: An increase in expression compared to basal level was observed for IL-10, IL-12 and IFN-gamma at 24 h and 6 days after exposure to probiotics with a different time pattern. No significant increase was observed for TNF-alpha and IL-6. Conclusion: The probiotics used in this study are able to evoke a specific immune response in human lymphocytes with prevalence of anti-inflammatory cytokines and IFN-gamma.

Translated title of the contributionIn vitro evaluation of immunomodulating activity of a food supplement containing three probiotics: L. plantarum P17630, L. paracasei I1688, L. salivarius I1794
Original languageItalian
Pages (from-to)65-71
Number of pages7
JournalTrends in Medicine
Volume10
Issue number1
Publication statusPublished - Jan 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'In vitro evaluation of immunomodulating activity of a food supplement containing three probiotics: L. plantarum P17630, L. paracasei I1688, L. salivarius I1794'. Together they form a unique fingerprint.

  • Cite this