Valutazione in vitro dell'attività immunomodulante di un integratore alimentare costituito da una miscela di tre specifici ceppi probiotici

L. plantarum P17630, L. paracasei I1688 e L. salivarius I1794

Translated title of the contribution: In vitro evaluation of immunomodulating activity of a food supplement containing three probiotics: L. plantarum P17630, L. paracasei I1688, L. salivarius I1794

Patrizia Malfa, Chiara Valsecchi, Lorenza Montagna, Melissa Mantelli, Annamaria Castellazzi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Probiotics have been proposed as a treatment for a lot of discomforts, both in children and adult patients. Obiective: To evaluate the in vitro activity of a food supplement containing three probiotics on the release of cytokines from immune cells of healthy individuals. Materials: The ability of three different probiotic strains (L. plantarum P17630, L. paracasei I1688 and L. salivarius I1794) in a ratio of 200:4.9:0.1 to stimulate the release of five cytokines (IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma) from peripheral blood mononuclear cells was evaluated at 24 h and 6 days. Results: An increase in expression compared to basal level was observed for IL-10, IL-12 and IFN-gamma at 24 h and 6 days after exposure to probiotics with a different time pattern. No significant increase was observed for TNF-alpha and IL-6. Conclusion: The probiotics used in this study are able to evoke a specific immune response in human lymphocytes with prevalence of anti-inflammatory cytokines and IFN-gamma.

Original languageItalian
Pages (from-to)65-71
Number of pages7
JournalTrends in Medicine
Volume10
Issue number1
Publication statusPublished - Jan 2010

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Probiotics
Dietary Supplements
Interleukin-12
Cytokines
Interleukin-10
Interleukin-6
Tumor Necrosis Factor-alpha
Blood Cells
Anti-Inflammatory Agents
In Vitro Techniques
Lymphocytes

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology (medical)

Cite this

Valutazione in vitro dell'attività immunomodulante di un integratore alimentare costituito da una miscela di tre specifici ceppi probiotici : L. plantarum P17630, L. paracasei I1688 e L. salivarius I1794. / Malfa, Patrizia; Valsecchi, Chiara; Montagna, Lorenza; Mantelli, Melissa; Castellazzi, Annamaria.

In: Trends in Medicine, Vol. 10, No. 1, 01.2010, p. 65-71.

Research output: Contribution to journalArticle

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