In vitro gallbladder motility in patients with radiolucent and radiopaque stones

M. A. Maselli, C. Messa, F. Pezzolla, G. Riezzo, M. L. Caruso, A. Di Leo

Research output: Contribution to journalArticle

Abstract

Twenty-five gallbladders were studied in vitro. Sixteen had radiolucent gallstones and 9 had radiopaque gallstones. The radiolucent gallstones had a cholesterol content of 94.17 ± 3.76% and the radiopaque gallstones had a cholesterol content of 56.6 ± 4.46%. Half the maximal response (ED50) to cholecystokinin octapeptide (CCK-OP) and to carbachol in strips from patients with radiolucent gallstones was 0.8 ±0.15 and 27.01 ± 3.74 × 10-7 M. respectively. In strips from patients with radiopaque gallstones, the ED50 was 0.4 ± 0.08 and 14.92 ± 3.07 × 10-7 M, respectively. The ED50 values to CCK-OP and carbachol were greater in strips from specimens with radiolucent gallstones than in strips from specimens with radiopaque gallstones (p <0.05). There was no significant difference in the maximal contractile response of the two groups. It can be concluded that gallbladder sensitivity to CCK-OP and carbachol can be modified in relation to differences in the cholesterol and calcium content of the stones.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalDigestion
Volume50
Issue number1
DOIs
Publication statusPublished - 1991

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Keywords

  • Carbachol
  • Cholecystokinin octapeptide
  • Gallbladder motility
  • Radiolucent gallstones
  • Radiopaque gallstones

ASJC Scopus subject areas

  • Gastroenterology

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