In vitro growth of human multiple myeloma: Implications for biology and therapy

F. Caligaris-Cappio, M. G. Gregoretti, P. Ghia, L. Bergui

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro data present a plausible scenario for the in vivo growth of human multiple myeloma that involves interaction between the monoclonal B-cell clone and the bone marrow (BM) microenvironment. A large series of adhesion and extracellular matrix molecules trap circulating plasma cell precursors within the BM, and a battery of locally released cytokines promote the growth and final differentiation of the B-cell clone. The cytokines released by malignant plasma cells recruit and activate BM stromal cells and T lymphocytes to produce other cytokines that can act in concert in a self- perpetuating mechanism of mutual help and recruitment that favors the progressive expansion of the malignant clone through an 'avalanche' effect. Further, most cytokines produced by malignant plasma cells, stromal cells, and activated T lymphocytes have osteoclast-activating properties, thus explaining why the expansion of the B-cell clone is matched by the activation and numerical increase of osteoclasts.

Original languageEnglish
Pages (from-to)257-271
Number of pages15
JournalHematology/Oncology Clinics of North America
Volume6
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Oncology

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