TY - JOUR
T1 - In vitro growth of human multiple myeloma
T2 - Implications for biology and therapy
AU - Caligaris-Cappio, F.
AU - Gregoretti, M. G.
AU - Ghia, P.
AU - Bergui, L.
PY - 1992
Y1 - 1992
N2 - In vitro data present a plausible scenario for the in vivo growth of human multiple myeloma that involves interaction between the monoclonal B-cell clone and the bone marrow (BM) microenvironment. A large series of adhesion and extracellular matrix molecules trap circulating plasma cell precursors within the BM, and a battery of locally released cytokines promote the growth and final differentiation of the B-cell clone. The cytokines released by malignant plasma cells recruit and activate BM stromal cells and T lymphocytes to produce other cytokines that can act in concert in a self- perpetuating mechanism of mutual help and recruitment that favors the progressive expansion of the malignant clone through an 'avalanche' effect. Further, most cytokines produced by malignant plasma cells, stromal cells, and activated T lymphocytes have osteoclast-activating properties, thus explaining why the expansion of the B-cell clone is matched by the activation and numerical increase of osteoclasts.
AB - In vitro data present a plausible scenario for the in vivo growth of human multiple myeloma that involves interaction between the monoclonal B-cell clone and the bone marrow (BM) microenvironment. A large series of adhesion and extracellular matrix molecules trap circulating plasma cell precursors within the BM, and a battery of locally released cytokines promote the growth and final differentiation of the B-cell clone. The cytokines released by malignant plasma cells recruit and activate BM stromal cells and T lymphocytes to produce other cytokines that can act in concert in a self- perpetuating mechanism of mutual help and recruitment that favors the progressive expansion of the malignant clone through an 'avalanche' effect. Further, most cytokines produced by malignant plasma cells, stromal cells, and activated T lymphocytes have osteoclast-activating properties, thus explaining why the expansion of the B-cell clone is matched by the activation and numerical increase of osteoclasts.
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M3 - Article
C2 - 1582973
AN - SCOPUS:0026566160
VL - 6
SP - 257
EP - 271
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 2
ER -