Misoprostol is a synthetic prostaglandin which is structurally related to PGE 1. Since PGE exerts negative effects on immune response, the possible effects of misoprostol on in vitro immune response was evaluated. To this end the mitogen (PHA) induced proliferation of peripheral mononuclear cells (PMNCs), the PMNC proliferation induced by anti-CD3, anti-CD2 and anti-CD28 monoclonal antibodies, and PHA-induced lymphokines (namely interleukin 2 and γ-interferon) secretion were evaluated by adding to cultures 2.5 ng/ml of misoprostol. The results of the present study demonstrate that misoprostol decreases these in vitro immunological parameters. This effect is also dose dependent.
|Number of pages||4|
|Journal||International Journal of Immunotherapy|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Immunology and Allergy