In vitro immune response to misoprostol (synthetic prostaglandin)

G. Ciprandi, A. Scordamaglia, F. Paolieri, M. A. Tosca, G. W. Canonica

Research output: Contribution to journalArticlepeer-review


Misoprostol is a synthetic prostaglandin which is structurally related to PGE 1. Since PGE exerts negative effects on immune response, the possible effects of misoprostol on in vitro immune response was evaluated. To this end the mitogen (PHA) induced proliferation of peripheral mononuclear cells (PMNCs), the PMNC proliferation induced by anti-CD3, anti-CD2 and anti-CD28 monoclonal antibodies, and PHA-induced lymphokines (namely interleukin 2 and γ-interferon) secretion were evaluated by adding to cultures 2.5 ng/ml of misoprostol. The results of the present study demonstrate that misoprostol decreases these in vitro immunological parameters. This effect is also dose dependent.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalInternational Journal of Immunotherapy
Issue number3
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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