Abstract
The T-cell requirement for the B-lymphocyte immunoglobulin synthesis induced by Pokeweed mitogen (PWM) and by Staphylococcus Aureus Cowan I (SAC) was investigated. We found that the PWM induced B-cell activation was controlled by an absolute Mytomicin-C resistant T-cell helper activity and by a Mytomicin-C sensible T-cell suppressor activity. On the other hand the SAC induced B-cell activation was less thymus dependent and was not influenced by Mytomicin-C treated or irradiated T cells. The different T-cell requirement could be an expression of different responding B-cell subpopulations.
| Original language | English |
|---|---|
| Pages (from-to) | 177-181 |
| Number of pages | 5 |
| Journal | Journal of Clinical and Laboratory Immunology |
| Volume | 17 |
| Issue number | 4 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Immunology
Cite this
Barcellini, W., Sguotti, C., Dall'Aglio, P., Garelli, S., & Meroni, P. L. (1985). In vitro immunoglobulin synthesis: T-cell requirement in pokeweed and Staphylococcus aureus B-cell activation. Journal of Clinical and Laboratory Immunology, 17(4), 177-181.