In vitro immunoglobulin synthesis: T-cell requirement in pokeweed and Staphylococcus aureus B-cell activation

W. Barcellini, C. Sguotti, P. Dall'Aglio, S. Garelli, P. L. Meroni

Research output: Contribution to journalArticle

Abstract

The T-cell requirement for the B-lymphocyte immunoglobulin synthesis induced by Pokeweed mitogen (PWM) and by Staphylococcus Aureus Cowan I (SAC) was investigated. We found that the PWM induced B-cell activation was controlled by an absolute Mytomicin-C resistant T-cell helper activity and by a Mytomicin-C sensible T-cell suppressor activity. On the other hand the SAC induced B-cell activation was less thymus dependent and was not influenced by Mytomicin-C treated or irradiated T cells. The different T-cell requirement could be an expression of different responding B-cell subpopulations.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalJournal of Clinical and Laboratory Immunology
Volume17
Issue number4
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Immunology

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