In vitro immunoglobulin synthesis: T-cell requirement in pokeweed and Staphylococcus aureus B-cell activation

W. Barcellini; C. Sguotti; P. Dall'Aglio; S. Garelli; P. L. Meroni

In vitro immunoglobulin synthesis: T-cell requirement in pokeweed and Staphylococcus aureus B-cell activation

W. Barcellini, C. Sguotti, P. Dall'Aglio, S. Garelli, P. L. Meroni

Research output: Contribution to journal › Article › peer-review

Abstract

The T-cell requirement for the B-lymphocyte immunoglobulin synthesis induced by Pokeweed mitogen (PWM) and by Staphylococcus Aureus Cowan I (SAC) was investigated. We found that the PWM induced B-cell activation was controlled by an absolute Mytomicin-C resistant T-cell helper activity and by a Mytomicin-C sensible T-cell suppressor activity. On the other hand the SAC induced B-cell activation was less thymus dependent and was not influenced by Mytomicin-C treated or irradiated T cells. The different T-cell requirement could be an expression of different responding B-cell subpopulations.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Journal of Clinical and Laboratory Immunology
Volume	17
Issue number	4
Publication status	Published - 1985

ASJC Scopus subject areas

Immunology

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abstract = "The T-cell requirement for the B-lymphocyte immunoglobulin synthesis induced by Pokeweed mitogen (PWM) and by Staphylococcus Aureus Cowan I (SAC) was investigated. We found that the PWM induced B-cell activation was controlled by an absolute Mytomicin-C resistant T-cell helper activity and by a Mytomicin-C sensible T-cell suppressor activity. On the other hand the SAC induced B-cell activation was less thymus dependent and was not influenced by Mytomicin-C treated or irradiated T cells. The different T-cell requirement could be an expression of different responding B-cell subpopulations.",

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year = "1985",

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AU - Barcellini, W.

AU - Sguotti, C.

AU - Dall'Aglio, P.

AU - Garelli, S.

AU - Meroni, P. L.

PY - 1985

Y1 - 1985

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