Abstract
The T-cell requirement for the B-lymphocyte immunoglobulin synthesis induced by Pokeweed mitogen (PWM) and by Staphylococcus Aureus Cowan I (SAC) was investigated. We found that the PWM induced B-cell activation was controlled by an absolute Mytomicin-C resistant T-cell helper activity and by a Mytomicin-C sensible T-cell suppressor activity. On the other hand the SAC induced B-cell activation was less thymus dependent and was not influenced by Mytomicin-C treated or irradiated T cells. The different T-cell requirement could be an expression of different responding B-cell subpopulations.
Original language | English |
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Pages (from-to) | 177-181 |
Number of pages | 5 |
Journal | Journal of Clinical and Laboratory Immunology |
Volume | 17 |
Issue number | 4 |
Publication status | Published - 1985 |
ASJC Scopus subject areas
- Immunology