In vitro immunomodulatory properties of tucaresol in HIV infection

Mario Clerici; Marta Cogliati; Giuliano Rizzardini; Fulvia Colombo; Sabrina Fossati; John Rhodes; Dorothy Bray; Stefania Piconi

doi:10.1006/clim.2000.4937

In vitro immunomodulatory properties of tucaresol in HIV infection

Mario Clerici, Marta Cogliati, Giuliano Rizzardini, Fulvia Colombo, Sabrina Fossati, John Rhodes, Dorothy Bray, Stefania Piconi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article

Abstract

The immunomodulatory properties of tucaresol (compound 589C80) were tested on in vitro antigen- and mitogen-stimulated proliferation and cytokine production by peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and healthy controls (HC). Results showed that tucaresol: (1) increases influenza A virus-, gp 160 peptide-, and HLA alloantigen-stimulated proliferation as well as interleukin (IL)-2 and interferon gamma (IFNγ) production by PBMC of HIV-infected individuals with higher CD4 counts (>500/μl) but had only a marginal immunomodulatory effect on PBMC of patients with lower CD4 counts (

Original language	English
Pages (from-to)	211-220
Number of pages	10
Journal	Clinical Immunology
Volume	97
Issue number	3
DOIs	https://doi.org/10.1006/clim.2000.4937
Publication status	Published - 2000

Keywords

Cytokine
HIV infection
Immune-based therapies
Immunity

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pathology and Forensic Medicine

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10.1006/clim.2000.4937

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Clerici, M., Cogliati, M., Rizzardini, G., Colombo, F., Fossati, S., Rhodes, J., Bray, D., & Piconi, S. (2000). In vitro immunomodulatory properties of tucaresol in HIV infection. Clinical Immunology, 97(3), 211-220. https://doi.org/10.1006/clim.2000.4937

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AU - Rhodes, John

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