In vitro immunomodulatory properties of tucaresol in HIV infection

Mario Clerici, Marta Cogliati, Giuliano Rizzardini, Fulvia Colombo, Sabrina Fossati, John Rhodes, Dorothy Bray, Stefania Piconi

Research output: Contribution to journalArticle

Abstract

The immunomodulatory properties of tucaresol (compound 589C80) were tested on in vitro antigen- and mitogen-stimulated proliferation and cytokine production by peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and healthy controls (HC). Results showed that tucaresol: (1) increases influenza A virus-, gp 160 peptide-, and HLA alloantigen-stimulated proliferation as well as interleukin (IL)-2 and interferon gamma (IFNγ) production by PBMC of HIV-infected individuals with higher CD4 counts (>500/μl) but had only a marginal immunomodulatory effect on PBMC of patients with lower CD4 counts (

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalClinical Immunology
Volume97
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Cytokine
  • HIV infection
  • Immune-based therapies
  • Immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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  • Cite this

    Clerici, M., Cogliati, M., Rizzardini, G., Colombo, F., Fossati, S., Rhodes, J., Bray, D., & Piconi, S. (2000). In vitro immunomodulatory properties of tucaresol in HIV infection. Clinical Immunology, 97(3), 211-220. https://doi.org/10.1006/clim.2000.4937