Abstract
The immunomodulatory properties of tucaresol (compound 589C80) were tested on in vitro antigen- and mitogen-stimulated proliferation and cytokine production by peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and healthy controls (HC). Results showed that tucaresol: (1) increases influenza A virus-, gp 160 peptide-, and HLA alloantigen-stimulated proliferation as well as interleukin (IL)-2 and interferon gamma (IFNγ) production by PBMC of HIV-infected individuals with higher CD4 counts (>500/μl) but had only a marginal immunomodulatory effect on PBMC of patients with lower CD4 counts (
| Original language | English |
|---|---|
| Pages (from-to) | 211-220 |
| Number of pages | 10 |
| Journal | Clinical Immunology |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Cytokine
- HIV infection
- Immune-based therapies
- Immunity
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
In vitro immunomodulatory properties of tucaresol in HIV infection. / Clerici, Mario; Cogliati, Marta; Rizzardini, Giuliano; Colombo, Fulvia; Fossati, Sabrina; Rhodes, John; Bray, Dorothy; Piconi, Stefania.
In: Clinical Immunology, Vol. 97, No. 3, 2000, p. 211-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro immunomodulatory properties of tucaresol in HIV infection
AU - Clerici, Mario
AU - Cogliati, Marta
AU - Rizzardini, Giuliano
AU - Colombo, Fulvia
AU - Fossati, Sabrina
AU - Rhodes, John
AU - Bray, Dorothy
AU - Piconi, Stefania
PY - 2000
Y1 - 2000
N2 - The immunomodulatory properties of tucaresol (compound 589C80) were tested on in vitro antigen- and mitogen-stimulated proliferation and cytokine production by peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and healthy controls (HC). Results showed that tucaresol: (1) increases influenza A virus-, gp 160 peptide-, and HLA alloantigen-stimulated proliferation as well as interleukin (IL)-2 and interferon gamma (IFNγ) production by PBMC of HIV-infected individuals with higher CD4 counts (>500/μl) but had only a marginal immunomodulatory effect on PBMC of patients with lower CD4 counts (
AB - The immunomodulatory properties of tucaresol (compound 589C80) were tested on in vitro antigen- and mitogen-stimulated proliferation and cytokine production by peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and healthy controls (HC). Results showed that tucaresol: (1) increases influenza A virus-, gp 160 peptide-, and HLA alloantigen-stimulated proliferation as well as interleukin (IL)-2 and interferon gamma (IFNγ) production by PBMC of HIV-infected individuals with higher CD4 counts (>500/μl) but had only a marginal immunomodulatory effect on PBMC of patients with lower CD4 counts (
KW - Cytokine
KW - HIV infection
KW - Immune-based therapies
KW - Immunity
UR - http://www.scopus.com/inward/record.url?scp=0033673771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033673771&partnerID=8YFLogxK
U2 - 10.1006/clim.2000.4937
DO - 10.1006/clim.2000.4937
M3 - Article
C2 - 11112360
AN - SCOPUS:0033673771
VL - 97
SP - 211
EP - 220
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 3
ER -