In vitro immunomodulatory properties of tucaresol in HIV infection

Mario Clerici, Marta Cogliati, Giuliano Rizzardini, Fulvia Colombo, Sabrina Fossati, John Rhodes, Dorothy Bray, Stefania Piconi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The immunomodulatory properties of tucaresol (compound 589C80) were tested on in vitro antigen- and mitogen-stimulated proliferation and cytokine production by peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and healthy controls (HC). Results showed that tucaresol: (1) increases influenza A virus-, gp 160 peptide-, and HLA alloantigen-stimulated proliferation as well as interleukin (IL)-2 and interferon gamma (IFNγ) production by PBMC of HIV-infected individuals with higher CD4 counts (>500/μl) but had only a marginal immunomodulatory effect on PBMC of patients with lower CD4 counts (

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalClinical Immunology
Volume97
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

HIV Infections
Blood Cells
CD4 Lymphocyte Count
HIV
Isoantigens
Influenza A virus
Mitogens
Interferon-gamma
Interleukin-2
Cytokines
Antigens
Peptides
In Vitro Techniques
tucaresol

Keywords

  • Cytokine
  • HIV infection
  • Immune-based therapies
  • Immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Clerici, M., Cogliati, M., Rizzardini, G., Colombo, F., Fossati, S., Rhodes, J., ... Piconi, S. (2000). In vitro immunomodulatory properties of tucaresol in HIV infection. Clinical Immunology, 97(3), 211-220. https://doi.org/10.1006/clim.2000.4937

In vitro immunomodulatory properties of tucaresol in HIV infection. / Clerici, Mario; Cogliati, Marta; Rizzardini, Giuliano; Colombo, Fulvia; Fossati, Sabrina; Rhodes, John; Bray, Dorothy; Piconi, Stefania.

In: Clinical Immunology, Vol. 97, No. 3, 2000, p. 211-220.

Research output: Contribution to journalArticle

Clerici, M, Cogliati, M, Rizzardini, G, Colombo, F, Fossati, S, Rhodes, J, Bray, D & Piconi, S 2000, 'In vitro immunomodulatory properties of tucaresol in HIV infection', Clinical Immunology, vol. 97, no. 3, pp. 211-220. https://doi.org/10.1006/clim.2000.4937
Clerici M, Cogliati M, Rizzardini G, Colombo F, Fossati S, Rhodes J et al. In vitro immunomodulatory properties of tucaresol in HIV infection. Clinical Immunology. 2000;97(3):211-220. https://doi.org/10.1006/clim.2000.4937
Clerici, Mario ; Cogliati, Marta ; Rizzardini, Giuliano ; Colombo, Fulvia ; Fossati, Sabrina ; Rhodes, John ; Bray, Dorothy ; Piconi, Stefania. / In vitro immunomodulatory properties of tucaresol in HIV infection. In: Clinical Immunology. 2000 ; Vol. 97, No. 3. pp. 211-220.
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